Inclusion Criteria:

• Patients with acute hypoxemic and/or hypercapnic respiratory failure.
• Patients requiring intubation and mechanical ventilation for more than 24 hours.
• VentCoach protocol is specific to volume controlled continuous mandatory ventilation (S-CMV).
• Patient who are admitted to RMH 10-3/10-4 and MB 6BGF ICUs.
• Age greater than or equal to 18 years.
• Patient’s legal representative should be able to provide informed consent to the study. Any participant speaking any language will be offered participation.

Exclusion Criteria:

• Intubation and mechanical ventilation for airway protection in the setting of procedures/surgeries; e.g. interventional radiology, surgery, or endoscopy.
• Intubation and mechanical ventilation due to drug overdose with expected extubation of less than 24 hours.
• Intubation and mechanical ventilation in the setting of cardiac arrest of primary cardiac etiology.
• Intubation and mechanical ventilation for a primary neurological etiology; e.g. increased intracranial pressure, tumor mass effect, ischemic/hemorrhagic stroke, status epilepticus, etc.
• Mechanical ventilation to be guided by esophageal balloon.
• Subject deprived of freedom, minor, subject under a legal protective measure.
• Change in end-of-life decision anticipated after enrollment (or estimated 6-month mortality rate of greater than 50%).

Note: Prone positioning is not a contraindication for participation.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 5/22/23. Questions regarding updates should be directed to the study team contact.