Dupilumab Treatment on Sinonasal Respiratory Symptoms and Sense of Smell in Ethnically Diverse Patients with Chronic Rhinosinusitis and Nasal Polyps

Overview

About this study

The purpose of this study is to to identify pathways by which dupilumab may “normalize” the immune response in patients with Chronic Rhinosinusitis and Nasal Polyps (CRSwNP) and prevent nasal polyp recurrence.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Patients with physician-diagnosed CRSwNP, with or without comorbid asthma that meet indication criteria for FDA-approved use of Dupixent.
  • Patients aged 18 years and older.
  • Patient willing to provide consent to be a participant in the study.
  • Patients with insurance that allows Dupixent coverage or Dupixent coverage obtained through Dupixent MyWay Program.

Exclusion Criteria:

  • Age under 18.
  • Suspected or diagnosed allergic fungal rhinosinusitis.
  • Suspected or diagnosed cystic fibrosis.
  • Dupixent coverage denied through insurance or Dupixent MyWay Program.
  • Patients who required a steroid taper in the preceding 30 days. However, patients on chronic steroids equal to ≤ 20 mg of prednisone daily, are eligible.
  • Patients who were on a different biologic medication in the preceding 3 months.
  • Patients with a diagnosis of EGPA/Churg-Strauss Sydnrome.
  • Pregnant patients.
  • Patients with inverted papilloma growth.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Elina Jerschow, M.D., M.S.

Open for enrollment

Contact information:

Eboni Patten C.S.T.

(507) 422-3988

Patten.Eboni@mayo.edu

More information

Publications

Publications are currently not available