Inclusion Criteria:

• Male or female ≥ 18 years.
• Provision of signed and dated informed consent form (may be completed by legal authorized representative [LAR] for those patients unable to provide consent; i.e., sedation/intubation).
• Stated willingness to comply with all study procedures and availability for the duration of the study, including follow-up assessments.
• Known coronary artery disease with planned intervention of either CABG requiring cardiopulmonary bypass use or PCI at Mayo Clinic Rochester.

Exclusion Criteria:

• Likelihood of not being able to return for follow-up visits and complete surveys; i.e., not expected to survive hospitalization, visual impairment or blindness, non-English speaking, unable to make follow-up appointments, dementia or other severe cognitive impairments, prisoner.
• Planned off-pump CABG.
• Emergent cases (either CABG or PCI).
• Planned or known procedures to occur in the upcoming year that will involve any spinal or general anesthesia (will be withdrawn if this occurs).
  • Note: if subject undergoes this during current hospitalization, okay to remain in study).
• Chronic renal disease (any stage) receiving dialysis.
• Medication use with epigenetic properties (hydroxychloroquine, methotrexate, 5-azacitidine, valproate, or levofloxacin) at time of enrollment or prior 3 weeks.
• Known pre-existing inherited dyslipidemias as defined by ICD-10 codes.
• Any cancer diagnosis received within the prior 5 years that has required chemotherapy and/or radiation treatment.
• Any systemic immunosuppressive medications in the equivalent of 5mg of prednisone within last 6 months.
• Pregnant individuals. A woman of child-bearing potential must have a negative pregnancy test performed prior to enrollment (either clinically or directed by the study).

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 4/30/2024. Questions regarding updates should be directed to the study team contact.