Metabolic Differences That Exist Between Women With and Without Gestational Diabetes Mellitus Twelve Months Following Pregnancy

Overview

About this study

The purpose of this study is to understand the metabolic differences that exist between women with and without Gestational Diabetes Mellitus (GDM) 12 months following pregnancy to help us clarify why women with GDM are at higher risk of type 2 diabetes.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Subjects will be recruited 1 year from their most recent live birth.
  • 30 with Gestational Diabetes Mellitus (GDM) in the preceding pregnancy.
  • 30 with no history of GDM.

Exclusion Criteria: 

  • Individuals < 20 or > 40 years at the preceding pregnancy.
  • Active systemic illness.
  • Preceding multiple gestation pregnancy.
  • Taking medication that affects glucose metabolism.
  • Upper GI surgery that alters gastric emptying.
  • Current BM I< 25kg/m^2.
  • For the GDM group, those with GDM in any pregnancy prior to the most recent pregnancy will be excluded (to reduce within group heterogeneity).
  • Currently pregnant or breastfeeding. At a screening visit, subjects will provide consent and undergo a history and physical. They will have an EKG, blood draw for complete blood count, fasting glucose, HbA1c and chemistry group, and a pregnancy test. Subjects will be excluded if HbA1c is > 5.6% or fasting glucose is > 100mg/dL. Body composition will be measured using dual-energy X-ray absorptiometry (iDXA scanner; GE Wauwatosa, WI).

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 4/18/23. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Aoife Egan, M.B., B.Ch., Ph.D.

Open for enrollment

Contact information:

Aoife Egan M.B., B.Ch., Ph.D.

(507) 284-4080

Egan.Aoife@mayo.edu

More information

Publications

Publications are currently not available