Inclusion Criteria

- Able to provide medical record release to confirm eligibility

- First, primary diagnosis of Stage I-IIIa breast cancer

- Post-menopausal at the time of diagnosis

- Post-surgery and completed primary treatment (i.e., surgery, chemotherapy, and/or
radiation therapy) 3-24 months prior to enrollment

- No evidence of possible cognitive impairment as assessed using the Telephone Interview
of Cognitive status (TICS-M)

- Self-report 20+ minutes of exercise on 2 or fewer days per week within the previous
six months

- Receive physician's clearance to participate in an exercise program

- Ability to complete assessments by themselves or with assistance

Exclusion Criteria:

- Pre- or peri-menopausal at the time of diagnosis with breast cancer

- Stage 0 breast cancer diagnosis OR metastatic disease

- Currently receiving or <3 months since receiving chemotherapy or radiation therapy for
cancer, or greater than 24 months post primary treatment

- Planned surgery during the intervention period

- Second cancer diagnosis (excluding non-invasive skin cancers; including breast cancer
recurrence)

- History of stroke, transient ischemic attack, other neurological disorders, or brain
surgery involving tissue removal as confirmed via clinical determination

- Clinically significant TICS-M score

- Not able to provide physician re-clearance for exercise if required based upon
clinically significant baseline exercise test

- Contraindications to functional magnetic resonance imaging (fMRI) in accordance with
the Mayo Clinic Department of Radiology safety protocols

- Clinically significant MRI scan as determined by physician review in which the
following is advised via radiologist overread: remarkable/abnormal limited diagnostic
brain image with recommended medical follow-up

- Enrolled in another physical activity program

- Unable to walk without assistance or devices

- Unwilling to complete study requirements

- Unwilling to be randomized to the exercise group or health education group

- Unable or unwilling to continuously wear and regularly sync/charge an activity tracker
during the study period

- Unable to travel regularly to the study locations for intervention sessions and data
collection

- Unwilling to return to enrolling institution for follow-up

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 5/25/23. Questions regarding updates should be directed to the study team contact.