Sulfated Glycosaminoglycan Adsorption on Retrieved TMJ Fossa Eminence Implants

Overview

About this study

The purpose of this study is to use Raman spectroscopy for the analysis of implants to detect sGAGs. Also, to remove and quantify unattached sulfated glycosaminoglycans on implant surfaces using specific biochemical assay, to assess the surface morphology of retrieval implants using scanning electron microscopy (SEM), and to conduct histological analysis of the surrounding tissue using safranin O/fast green staining to detect any depletion or damage to the tissue matrix.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Undergoing TMJ metal fossa implant removal in the normal course of disease treatment.

Exclusion Criteria:

  • Subject refusal to participate.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 7/31/23. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

William Fillmore, M.D., D.M.D.

Open for enrollment

Contact information:

William Fillmore M.D., D.M.D.

(507) 284-3193

Fillmore.Jonathan@mayo.edu

More information

Publications

Publications are currently not available