Selective Serotonin Inhibitor-Induced Changes in the Gut Microbiome in Depression

Overview

About this study

The purpose of this study is to uncover the main effects of selective serotonin inhibitor-induced (SSRI) therapy on the human microbiota, the relationship to treatment response, and commonalities with alterations found in our mouse model.  

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • ≥ 20 years of age
  • Have not been under antidepressant therapy previously.
  • Receiving outpatient care for nonpsychotic major depressive disorder.
  • Scheduled to receive selective serotonin inhibitor-induced (SSRI) therapy.

Exclusion Criteria:

  • Concurrent antidepressant therapy.
    Concurrent antibiotic treatment.
  • Co-existing conditions (obesity, BMI > 30).
  • Previous history of abdominal surgery (e.g., bowel resection).
  • Psychiatrically hospitalized or in an active suicidal crisis requiring hospitalization.
  • Currently undergoing electroconvulsive therapy, transcranial magnetic stimulation, or deep brain stimulation.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 3/28/23. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

John Fryer, Ph.D.

Contact us for the latest status

Contact information:

Nashali Massa

(787) 210-5305

Massa.Nashali@mayo.edu

More information

Publications

Publications are currently not available