Inclusion Criteria:

• Adults (age ≥ 18) with PICS defined as admitted to the ICU for more than 48 hours with any of the following conditions: respiratory failure of any cause requiring mechanical ventilation ≥ three days, any shock requiring vasopressors and/or inotropes, development of delirium during the ICU stay, , and cardiac arrest during the index hospital admission; AND
• A HABC-M-SR score > 12 points.

Exclusion Criteria:

• Any mechanical ventilation in the last two months before the index ICU admission
• ≥ 5 days in the ICU over the previous month before the index ICU admission
• Receiving hospice or palliative care
• Severe uncontrolled psychological or psychiatric disorders, e.g., schizophrenia, bipolar disorder, struggling to cope as a result of their personality disorder, uncontrolled substance abuse (alcoholism, illegal drugs) homelessness would make them unsuitable for the intervention
• A co-morbidity so severe it would prevent the patient from engaging fully in the intervention/ control, e.g., progressive cancer, anoxic brain injury, severe rheumatoid arthritis or osteoarthritis, multiple sclerosis, chronic widespread pain syndrome, previous cerebral vascular event that the patient would not be able to participate in PR
• Patients with moderate/severe cognitive impairment per medical records screening
• Inability to obtain informed consent.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 7/17/23. Questions regarding updates should be directed to the study team contact.