Stabilizing Autologous Tregs in Psoriatic Arthritisto Protect Target Joint and Tendon Tissues

Overview

About this study

The purpose of this study is to evaluate the phenotype, stability, functionality, transcriptome and TCR repertoire of peripheral vs synovial Tregs from PsA patients and HCs. Additionally, to establish a HIS mouse model of PsA to evaluate autoimmune responses against the joint and tendon tissues, and to evaluate the potential of CD2-KO Tregs in protecting human joint and tendon cells from autoreactive immune responses in vivo.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Patients ≥ 18 years of age.
  • Patients with a medical diagnosis consistent with their population group and the objectives of this study.

Exclusion Criteria: 

  • Patients with other significant inflammatory or autoimmune diseases not relevant to the groups defined in this study.
  • Patients with a history of chronic infections, including tuberculosis or hepatitis B or C.
  • Pregnant of lactating women.
  • Patients under the age of 18.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 8/25/23. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Mohsen Khosravi Maharlooei, M.D.

Open for enrollment

Contact information:

Mohsen Khosravi Maharlooei M.D.

KhosraviMaharlooei.Mohsen@mayo.edu

More information

Publications

Publications are currently not available