Families Genetic Determinants for High Penetrance of Type 1 Diabetes

Overview

About this study

The purpose of this study is to collect genetic material from individuals belonging to families with high prevalence of Type 1 Diabetes and perform whole exome sequencing to identify genetic risk determinants associated with this high prevalence. In addition, antibody panels from enrolled individuals will be reviewed to determine any correlation to identified genetic determinates.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Individuals aged 3-80 years with a clinical diagnosis of Diabetes Mellitus, Type I (T1D) with at least one (1) sibling also clinically diagnosed with Diabetes Mellitus, Type I (T1D) (*these individuals to be referred to as “Case Subjects”).
  • Individuals aged > 18 years who are biologically related to a case subject (to include biological siblings, direct line ancestors (parents, grandparents) or descendants (children, grandchildren)).
  • Individuals aged < 18 years of age who are biologically related to a case subject and do not have a diagnosis of T1D (necessary to determine the genetic basis of T1D occurrence in related family members).

Exclusion Criteria: 

  • Individuals aged < 18 years of age who are not biologically related to a case subject and do not have a diagnosis of T1D (pediatric normal donors will not be prospectively recruited).

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 11/10/23. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Quinn Peterson, Ph.D.

Open for enrollment

Contact information:

CRM Biotrust

MAYOCLINICBIOTRUST@mayo.edu

More information

Publications

Publications are currently not available