Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria:
1. Male or female, 22-85 years of age.
2. English speaking participants*
3. Documented history of symptomatic or asymptomatic paroxysmal or persistent AF. The
duration of AF must have been > 30 seconds as documented by an external monitor or
present on 12-lead ECG.
4. CHA2DS2-VASC score of 1-4 without prior stroke or Transient Ischemic Attack (TIA)**
5. The participant is on a DOAC at the time of screening.
6. Willing and able to comply with the protocol, including:
- Possession of a smartwatch-compatible smartphone (iPhone that supports the latest
shipping iOS) with a cellular service plan
- Be willing to wear the Apple watch at least 14 hours a day
- Expected to be within cellular service range at least 80% of the time
7. Willing and able to discontinue DOAC
8. The participant is willing and able to provide informed consent.
Exclusion Criteria:
1. Valvular or permanent atrial fibrillation.
2. Current treatment with warfarin and unwilling or unable to take a DOAC.
3. The participant is a woman who is pregnant, nursing, or of child-bearing potential and
is not on birth control.
4. The participant is being treated with chronic aspirin, another anti-platelet agent, or
chronic NSAIDS outside of current medical guidelines (e.g., primary stroke prevention
in patients with atrial fibrillation, primary prevention of cardiovascular events,
pain relief, fever, gout) and is unwilling or unable to discontinue use for the study
duration.
5. Existing cardiac rhythm device or indication for a permanent pacemaker, Implantable
Cardioverter-Defibrillator (ICD) or Cardiac Resynchronization Therapy (CRT) device or
planned insertable cardiac monitor.
6. Any documented single AF episode lasting ≥ 1 hour on screening external cardiac
monitor of >=6 days duration.
7. Mechanical prosthetic valve(s) or severe valve disease.
8. Hypertrophic cardiomyopathy.
9. Participant needs Direct Oral Anticoagulation (DOAC) for reasons other than preventing
stroke or arterial embolism resulting from AF (i.e., preventing Deep Vein Thrombosis
(DVT) or Pulmonary Embolism (PE)) or needs permanent Oral Anticoagulant (OAC) (i.e.,
congenital heart defects, prosthetic heart valve).
10. Participants deemed high risk for non-cardioembolic stroke (i.e., significant carotid
artery disease defined as stenosis > 75%) based on the investigator's discretion.
11. The participant is enrolled, has participated within the last 30 days, or is planning
to participate in a concurrent drug and/or device study during the course of this
clinical trial. Co-enrollment in concurrent trials is only allowed with documented
pre-approval from the study manager; there is no concern that co-enrollment could
confound the results of this trial.
12. The participant has a tattoo, birthmark, or surgical scar over the dorsal wrist area
on the ipsilateral side that the AFSW may be worn.
13. The participant has a tremor on their ipsilateral side that the AFSW may be worn.
14. Any concomitant condition that, in the investigator's opinion, would not allow safe
participation in the study (e.g., drug addiction, alcohol abuse).
15. Known hypersensitivity or contraindication to direct oral anticoagulants.
16. Documented prior stroke (ischemic or hemorrhagic) or transient ischemic attack.
17. Reversible causes of AF (e.g., cardiac surgery, pulmonary embolism, untreated
hyperthyroidism). AF ablation does not constitute reversible AF.
18. > 5% burden premature atrial or ventricular depolarizations on any given calendar day
on pre-enrollment cardiac monitoring.
19. History of atrial flutter that has not been treated with ablation (participants in
atrial flutter and have been ablated are eligible for enrollment).
20. Stage 4 or 5 chronic kidney disease.
21. Conditions associated with an increased risk of bleeding:
- Major surgery in the previous month
- Planned surgery or intervention in the next three months.
- History of intracranial, intraocular, spinal, retroperitoneal, or atraumatic
intra-articular bleeding
- Gastrointestinal hemorrhage within the past year unless the cause has been
permanently eliminated (e.g., by surgery)
- Symptomatic or endoscopically documented gastroduodenal ulcer disease in the
previous 30 days
- Hemorrhagic disorder or bleeding diathesis
- Need for anticoagulant treatment for disorders other than AF
- Required use of non-aspirin antiplatelet agents (i.e., Plavix) at time of
enrollment
- Uncontrolled hypertension (Systolic Blood Pressure (SBP) >180 mmHg and/or
Diastolic Blood Pressure( DBP) >100 mmHg)
- Spanish-only speakers may be included in the future at select sites where
consent forms are appropriately translated.
- Congestive heart failure defined as: The presence of signs and symptoms
of either right (elevated central venous pressure, hepatomegaly,
dependent edema) or left ventricular failure (exertional dyspnea,
cough, fatigue, orthopnea, paroxysmal nocturnal dyspnea, cardiac
enlargement, rales, gallop rhythm, pulmonary venous congestion) or
both, confirmed by non-invasive or invasive measurements demonstrating
objective evidence of cardiac dysfunction and/or ejection fraction <
40%
Note: Other protocol defined Inclusion/Exclusion Criteria may apply.
Eligibility last updated 10/9/23. Questions regarding updates should be directed to the study team contact.