Inclusion Criteria:

2 groups comprised of female and male adults:

• SCI cohort (n=25):
  • Aged 18-50;
  • Neurological level of injury at or below C6;
  • American Spinal Association Impairment Scale (AIS) injury A-C;
  • > 24 months post injury;
  • Non-injured able-bodied control cohort (n=15);

• Note that control participants will be matched by age and sex to the SCI cohort.

Exclusion Criteria:

• Clinical diagnosis of heart disease, hypertension, coronary disease, diabetes, or other neurological diseases (outside of SCI).
• Cancer.
• Pregnant women.
• Underweight or obese individuals (body mass index < 18.5 or > 30.0 kg/m^2).
• Regularly taking medication that may influence blood flow to the skin (e.g., antihistamines, beta-blockers, prednisone, etc.).
• Use of amphetamines (Ritalin, Adderall, Concerta) in the past 48 hours.
• Those with SCI with extreme spasticity (to avoid spontaneous contraction, as evaluated by study physician).

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 11/9/23. Questions regarding updates should be directed to the study team contact.