Metabolic Dysfunction-Associated Steatotic Liver Disease Altered Fructose Absorption

Overview

About this study

The purpose of this study is to define intestinal dietary fructose absorption in lean and obese subjects with MASLD. Also, to identify and characterize epigenetically controlled transcription factors associated with intestinal hyperabsorption of dietary fructose in MASLD.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Lean and obese adults aged 18 years or over diagnosed with MASLD, and non-MASLD individuals subjected to EGD for routine clinical indications as part of standard care.

Exclusion Criteria: 

  • Adults unable to consent.
  • Pregnant women (confirmed clinically prior to standard of care procedures).
  • Prisoners, patients with known genetic variants associated with NAFLD (e.g., PNPLA3 or TM6SF2).
  • Patients with other liver diseases such as viral hepatitis.
  • Autoimmune hepatitis, or alcoholic liver disease.
  • Patients with a history of malabsorptive disease such as celiac disease or inflammatory bowel disease.
  • Patients taking medications known to cause hepatic steatosis will be excluded.

Note: Other protocol defined Inclusion/Exclusion criteria may apply.

Eligibility last updated 8/31/23. Questions regarding updates should be directed to the study team contact

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Dilhana Badurdeen, M.B.B.S., M.D.

Open for enrollment

Contact information:

Dilhana Badurdeen M.B.B.S., M.D.

Badurdeen.Dilhana@mayo.edu

More information

Publications

Publications are currently not available