Inclusion Criteria:

- Have a histopathological diagnosis (fresh or banked tumor biopsy sample collected
within the last 3 years) consistent with locally advanced or metastatic conventional
chondrosarcoma Grades 1, 2, or 3 and not eligible for curative resection.

- Have at least one BICR-confirmed measurable lesion as defined by RECIST v1.1.
Participants who have received prior radiation therapy are eligible provided
measurable disease falls outside of the treatment field or within the field and has
shown ≥20% growth in size since post-treatment assessment.

- Have received 0 or 1 prior systemic treatment regimen in the advanced/metastatic
setting for chondrosarcoma.

- Have radiographic progression/recurrence of disease according to RECIST v1.1 defined
as:

1. Radiographic progression of disease (local and/or distant) documented by 2
imaging assessments performed no more than 6 months (±2 weeks) apart within 12
months before randomization.

OR

2. Any recurrence of disease (local and/or distant) after complete surgical
resection and documented by imaging within 6 months (±2 weeks) before
randomization.

- Have documented IDH1 gene-mutated disease (from a fresh tumor biopsy or the most
recent banked tumor tissue available that was sourced from either a primary or
metastatic tumor lesion) based on central laboratory testing (R132C/L/G/H/S mutation
variants tested)

- Have recovered from any clinically relevant sequelae and toxic effects of any prior
surgery, radiotherapy, or other therapy intended for the treatment of cancer.

Exclusion Criteria:

- Are unable to swallow oral medication.

- Pregnant or lactating women.

- Are participating in another interventional study at the same time; participation in
noninterventional registries or epidemiological studies is allowed.

- Have received prior therapy with an IDH1 inhibitor

- Have received systemic anticancer therapy <2 weeks prior to randomization (for
investigational or immune-based anticancer therapy <4 weeks).

- Have received radiotherapy <2 weeks prior to randomization.

- Have known symptomatic brain metastases requiring steroids >10 mg per day prednisone
(or equivalent). Participants with previously diagnosed brain metastases are eligible
if they have completed their treatment and have recovered from the acute effects of
radiation therapy or surgery prior to randomization, have discontinued or reduced
corticosteroid treatment <=10 mg per day for these metastases for at least 4 weeks and
have radiographically stable disease of brain lesions for at least 3 months prior to
randomization.

- Have a history of another primary cancer, with the exception of: a) curatively
resected non-melanoma skin cancer; b) curatively treated carcinoma in situ; or c)
pT1-2 prostatic cancer Gleason score <6 or d) participant is free of other primary
solid or liquid tumor for ≥ 1 year prior to the start of study treatment and, in the
opinion of the Investigator, the disease will not affect participant's outcome in the
setting of current chondrosarcoma diagnosis.

- Have had major surgery within 4 weeks prior to randomization.

- Have significant active cardiac disease within 6 months prior to randomization,
including New York Heart Association (NYHA) Class III or IV congestive heart failure;
myocardial infarction; unstable angina; and/or stroke.

- Have LVEF <40% by ECHO scan (or by other methods according to institutional practice)
obtained within 28 days prior to randomization.

- Have a heart-rate corrected QT interval (using Fridericia's formula) (QTcF) ≥ 450 msec
or other factors that increase the risk of QT prolongation or arrhythmic events (eg,
heart failure, hypokalemia, family history of long QT interval syndrome). Participants
with a bundle branch block combined with a prolonged QTcF interval may be permitted
based on local cardiology assessment.

- Have known medical history of progressive multifocal leukoencephalopathy (PML).

Note: Other protocol defined Inclusion/Exclusion criteria may apply.

Eligibility last updated 12/5/23. Questions regarding updates should be directed to the study team contact.