Peripheral Mechanisms of Cardiovascular Control in Heart Failure

Overview

About this study

The purpose of this study is to determine how heart failure impacts blood pressure responses during exercise. 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • HFpEF Patients: (≥18 yrs) will have no history of dangerous arrhythmias, have a body mass index ≤ 40kg/m2, currently be non-smokers with <20 pack year history and be able to exercise (i.e. without significant orthopedic limitations or musculoskeletal disorders limiting their ability to exercise). Although HF medications may influence multiple physiologic systems, we feel it is important, practical, and safe to study these patients under conditions of optimal care. Concurrent withdrawal of ACE-inhibitor, beta-blocker, digoxin, and/or diuretic therapies would likely be associated with moderate decompensation in a high proportion of patients. Accordingly, the impact of our studies will be generalizable to HF patients receiving standard optimized pharmacologic therapy, consistent with the general community. All patients will be managed by their primary care physician or cardiologist with additional review by the study team prior to enrollment to ensure inclusion and exclusion criteria have been satisfied and participation in exercise testing is safe.
  • Control participants: Adults (≥18 years of age) in the absence of a history of HFpEF or HFrEF, pulmonary, neurologic, orthopedic, or other diseases affecting the neuromuscular system. Controls will be matched for age and sex. Additional inclusion criteria include: BMI ≤40kg/m2, current non-smokers with smoking history <15 pack years, and those who are able to engage in exercise (i.e. without significant orthopedic limitations or musculoskeletal disorders limiting their ability to exercise).

Exclusion Criteria:

  • history of dangerous arrhythmias
  • body mass index >40 kg/m2
  • current smokers and/or smoking history >20 pack years
  • pregnant women (testing will be done by research team if requested)
  • creatinine value greater than or equal to 1.3 mg/dL (initial screen via clinical record within the past 6 months and this will be assessed on Visit 1); or  individuals who are not able to engage in exercise
  • For individuals agreeing to undergo dual energy x-ray absorptiometry (DEXA) scanning for measurement of body composition as part of their study visit, additional exclusion criteria apply: recently administered gastrointestinal contrast or radionuclides; severe degenerative changes or fracture deformity in measurement areas; or inability to attain correct position and/or remain motionless for the measurement period.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 4/10/2024. Questions regarding updates should be directed to the study team contact.

 

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Joshua Smith, Ph.D., M.S.

Open for enrollment

Contact information:

Eric Bruhn M.A.

(507) 422-0220

Bruhn.Eric@mayo.edu

More information

Publications

Publications are currently not available