Inclusion Criteria: 

• Age ≥18 to ≤ 80 years old

  - Acute intermediate-risk PE, defined as:
     - Intraluminal filling defect in segmental or larger vessels on computed tomography pulmonary angiography or high-probability ventilation/perfusion scan AND
     - Evidence of right ventricular enlargement by computed tomography (RV to LV ratio >1) or echocardiography; and/or right ventricular dysfunction by transthoracic echocardiography. These imaging characteristics must be in the setting of acute PE rather than explained by a prior chronic condition.

  -Acute high-risk PE, defined as:
     - Intraluminal filling defect in segmental or larger vessels on computed tomography pulmonary angiography or high-probability ventilation/perfusion scan AND
     - Evidence of right ventricular enlargement by computed tomography (RV to LV ratio >1) or echocardiography; and/or right ventricular dysfunction by transthoracic echocardiography. These imaging characteristics must be in the setting of acute PE rather than explained by a prior chronic condition; AND
     - Hypotension (systolic blood pressure < 90 mm Hg sustained for more than 15 minutes; or requiring vasopressors) or cardiogenic shock due to acute pulmonary embolism.

Exclusion Criteria: 

• Inability to perform 6MWD. (may be self-reported or as deemed by physical therapy during inpatient evaluation).
  • If patient requires supplemental oxygen during ambulation, this does not exclude patient from participation and will be noted during eCRF.
• Prior history of pulmonary embolism.
• History of CTEPH or pulmonary arterial hypertension.
• Unable to read a questionnaire in English.
• Unable to return for baseline, 3- or 6-month follow-up visit.
• Pregnancy-associated pulmonary embolism.
• Life expectancy <1 year based on comorbidities.
• Unable/unwilling to provide informed written consent

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 8/30/2024. Questions regarding updates should be directed to the study team contact.