Measurements During Exercise to Improve Clinical Diagnostics in CV Stress Testing

Overview

About this study

The purpose of this study is to utilize the soluble gas method to simultaneously quantify SV, cardiac output (Q), lung-to-lung circulation time (LLCT) and tissue O2 extraction, complementing existing gas exchange methods to assess ability to improve sensitivity and accuracy of interpretation of cardiac limitation from CPETs.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Must be 18 years or older
  • Female subjects must not be pregnant
  • Scheduled for a cardiopulmonary exercise test as a part of their clinical care

Exclusion Criteria:

  • History of:
    • Neurological disease (e.g. Alzheimer’s disease, or other brain-related disease)
    • Aneurysm
  • If currently has:
    • Uncontrolled epilepsy
    • Moderate-severe chronic obstructive pulmonary disease
    • Uncontrolled moderate-severe asthma
    • Moderate-severe bronchiectasis
    • Moderate-severe interstitial lung disease, requiring the use of supplemental oxygen
    • A necessity for supplemental oxygen, for any reason
    • Uncontrolled myocardial ischemia or angina
    • Uncontrolled heart arrythmias
    • Heart or lung infection (e.g. myocarditis or pericarditis)
    • Left main coronary artery stenosis
    • Moderate-severe aortic stenosis
    • Pulmonary embolism, pulmonary infarction or other blood clots
    • Chronic kidney disease
    • Chronic liver disease

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 10/09/2024. Questions regarding updates should be directed to the study team contact.

 

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Bryan Taylor, Ph.D.

Contact us for the latest status

Contact information:

Jordan Parks

(480) 301-4511

Parks.Jordan@mayo.edu

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Courtney Wheatley-Guy, Ph.D.

Open for enrollment

Contact information:

Jordan Parks

(480) 301-4511

Parks.Jordan@mayo.edu

More information

Publications

Publications are currently not available