Renal Function Using Quantitative MRI, Histopathology, and Liquid Biomarkers

Overview

About this study

The purpose of this study is to evaluate a comprehensive multiparametric protocol for the assessment of functional characteristics to non-invasively differentiate the physiological changes in the CKD pathology vs. normal kidneys and validate using histopathology and fluid biomarkers.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria: 

  • Individuals with CKD, AKI, Sickle Cell Disease, diabetes, kidney transplant, or healthy volunteer.
  • 18-80 years of age.
  • Consents to undergo MRI, and/or consent to use clinical biopsies for histopathology and optional consent for Blood collection.

Exclusion Criteria: 

  • Pregnancy
  • Contraindicated for MRI including but not limited to pacemakers.
  • MRI non-compatible implants, certain spine simulation devices etc.
  • Sedation

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 11/25/2024. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Ananth Madhuranthakam, Ph.D.

Contact us for the latest status

Contact information:

Ryan Jacobson

Jacobson.Ryan1@mayo.edu

More information

Publications

Publications are currently not available