Cost-Effective Strategies to Improve Rehabilitative Medicine for Heart Failure Patients with Preserved Ejection Fraction
Overview
Tab Title Description
Study type
InterventionalDescribes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study IDs
Site IRB
- Scottsdale/Phoenix, Arizona: 15-008854
Sponsor Protocol Number: 15-008854
About this study
Thte purpose of this study is to determine the impact of acute interval-style exercise training, with or without essential amino acid ingestion, on markers of muscle turnover and mitochondrial biogenesis. The study also aims to determine the impact of acute interval-style exercise training, with or without essential amino acid ingestion, on skeletal muscle satellite cell and myonuclei content.
Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria:
- Age 60+ years of age
- Able to communicate meaningfully with the investigator and must be legally competent to provide written informed consent.
- Diagnosed with HFpEF as per established echocardiographic criteria (New York Heart Association Class II-III)
- Patients that are taking anticoagulants will need to have an INR < 3
Exclusion Criteria:
- Unstable angina, myocardial infarction in the past 4 weeks
- Uncompensated heart failure
- New York Heart Associationclass IV symptoms, complex ventricular arrhythmias, symptomatic severe aortic stenosis, acute pulmonary embolus, acute myocarditis, untreated high-risk proliferative retinopathy, recent retinal hemorrhage, uncontrolled hypertension, baseline blood screening abnormalities
- Medication non-compliance
- Medical / orthopedic conditions precluding exercise
- Exercise training (>2 weekly sessions of moderate to high intensity aerobic or resistance exercise)
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
More information
Publications
Publications are currently not available