A Study of Using Ultrasound Shear Wave Elastography to Evaluate Eosinophilic Esophagitis
Overview
Tab Title Description
Study type
ObservationalDescribes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study IDs
Site IRB
- Rochester, Minnesota: 15-001488
Sponsor Protocol Number: 15-001488
About this study
The purpose of this study is to investigate the use of noninvasive ultrasound shear wave elastography and ultrasound blood vessel imaging to evaluate eosinophilic esophagitis.
Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria:
- Controls
- Not on inhaled or systemic steroids, proton pump inhibitors, H2 blockers or Leukotriene inhibitors
- Adults and children without known history of gastrointestinal or atopic disease and have none of the following symptoms
- Abdominal pain
- Vomiting
- Dysphagia
- Failure to thrive
- Food impaction
- Heart burn
- Acid regurgitation
- Cough
- Asthma
- Food allergy
- Environmental allergy
- Subjects
- Known EoE
- Found to have endoscopic and pathologic findings suggestive of EoE
- Have 15 or greater eosinophils/ hpf on upper endoscopy biopsies (must have been on a PPI for 8 weeks prior to procedure)
- Known or suspected EoE
- Underwent upper endoscopy to evaluate
- Vomiting
- Abdominal pain
- Dyspepsia
- Heart burn
- Dysphagia
Exclusion Criteria:
- Previous esophageal surgery
- Known congenital abnormality of the esophagus such as
- TEF
- Esophageal web
- Bronchial remnants
- Esophageal cleft
- Known celiac disease
- Known inflammatory bowel disease or other GI inflammatory inflammatory disease
- Body mass index (BMI) > 35
- Unreliable ultrasound images
- Adults lacking capacity to consent
- Prisoners
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
| Mayo Clinic Location |
Status |
|
Rochester, Minn.
Mayo Clinic principal investigator Shigao Chen, Ph.D. |
Closed for enrollment |
|
More information
Publications
Publications are currently not available