Registration – Inclusion Criteria

1. Age ≥ 18 years.
2. Histologic or cytologic proven breast cancer or colon cancer (Stage I, II or III)
3. Treated with chemotherapy and surgery
4. Treatment has been completed (except hormone therapy) for ≥90 days prior to registration.
5. No known evidence of disease
6. Men or women with a history of CRF as defined by a score ≥ 4 on the numeric analogue scale (0 – 10) (Eligibility Question Fatigue Scale; Appendix I).
7. Presence of CRF ≥30 days prior to registration.
8. The following laboratory values obtained ≤180 days prior to registration.
   • Hemoglobin ≥11.0 g/dL
   • SGOT ≤1.5X ULN
   • Creatinine ≤1.2 X ULN
9. Ability to complete questionnaire(s) in English by themselves or with assistance.
10. Provide written informed consent.
11. Willing to return to enrolling institution for follow-up of the study and Optional Crossover (if applicable).
12. Willing to provide blood samples for correlative research purposes.
13. Negative pregnancy test done ≤7 days prior to registration, for women of childbearing potential only.

Registration – Exclusion Criteria

1. Hypersensitivity to ginseng
2. Use of ginseng capsules for fatigue, within the last 12 months
3. Uncontrolled hypertension ≥2 times as noted in medical history (diastolic blood pressure > 100, systolic > 160) ≤90 days prior to registration.
4. Currently using any other pharmacologic agent to specifically treat fatigue including psychostimulants, antidepressants, etc., although antidepressants used to treat items other than fatigue (such as hot flashes) are allowed if the patient has been on a stable dose for ≥ 30 days prior to registration and plans to continue for ≥ 30 days after registration.  Erythropoietin agents to treat anemia are allowed.
5. Known brain metastasis or primary CNS malignancy.
6. Chronic oral or intravenous systemic steroid use (defined as being used on a regular basis or who have a problem that has required ongoing use of steroids in the last 180 days for greater than 7 days).
7. Diabetes (defined by being on oral hypoglycemics or insulin).
8. Psychiatric disorder such as severe depression, manic depressive disorder, obsessive compulsive disorder or schizophrenia. (Defined per medical history).
9. Major surgery ≤28 days prior to registration.
10. Any of the following:
    • Pregnant women
    • Nursing women
    • Women of childbearing potential who are unwilling to employ adequate contraception
11. Treatable causes of fatigue have not been ruled out, at least by history and exam criteria, by the treating provider, such as uncontrolled pain, hypothyroidism, or insomnia.  NOTE: If these are considered to be the primary cause for the patient’s fatigue then the patient is not eligible for this trial.
12. Patients with pain requiring opioid pain medication.  NOTE: Over the counter analgesics such as Tylenol or ibuprofen are allowed.
13. New use of Ambien and/or other benzodiazepines  ≤30 days prior to registration.
14. New use of sleep aids including Melatonin ≤30 days prior to registration.
15. Use of full anticoagulant doses of coumadin or heparin (Exception: 1 mg/day of coumadin for preventing catheter clots is allowed).
16. Use of MAOI inhibitors.
17. Patients scoring greater than 4 on a 0 to 10 scale with regard to sleep troubles or pain (Appendix I).
18. Patients planning to start any type of cancer therapy during the 8 week, double blind, course of the study, once randomized on the study.
19. Patients with malnutrition, active infection, significant pulmonary disease and cardiovascular disease as determined by the physician as they could impact fatigue.
20.  Use of any over the counter herbal/dietary supplement marketed for fatigue or energy (for example, products containing any type of ginseng, rhodiola rosea, high doses of caffeine, guarana, or anything called an “adaptogen”).
21. Co-morbid systemic illnesses or other severe concurrent disease which, in the judgment of the investigator, would make the patient inappropriate for entry into this study or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens.  
22. Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
23. Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm.
24. History of myocardial infarction ≤180 days prior to registration, or congestive heart failure requiring use of ongoing maintenance therapy for life-threatening ventricular arrhythmia

Crossover Re-registration – Inclusion Criteria

1. Treatment cannot begin prior to re-registering to the crossover phase and will ideally begin ≤ 7 days after registration for the crossover phase.