Inclusion Criteria:

• Age 18 years and older.
• Must have a Mayo Clinic MRN number.
• Normal subjects must not have any confounding medical conditions.

Exclusion Criteria:

• Any ‘undefined’ metallic implants or foreign bodies inside the body.
• Implanted active devices such as cardiac defibrillators/pacemakers, deep brain stimulators, vagus nerve stimulators, intrathecal pumps, cochlear implants.
• Devices, or residual parts thereof left in the body such as cardiac pacer wires, which provide life assist, bone growth or pain management.
• Structural support devices, screws, or wires in bone that are near the spinal cord or temperature sensitive organs.
• Reconstructive metallic implants near the orbits external devices, medicinal patches, piercings, jewelry, clothing or hair accessories (such as wigs, weaves and extensions) within to the radiofrequency coil that cannot be removed from the body.
• Pregnancy.
• Tattoos located within to the radiofrequency coil.
• Permanent facial makeup (for brain scanning).
• Metallic fragment in the eye.
• Colored contact lens.
• Fever / elevated temperature.
• Suffer from claustrophobia.

Eligibility last updated 6/8/23. Questions regarding updates should be directed to the study team contact.