Inclusion Criteria:

• Subjects who are not in clinical response or clinical remission after completing 12 weeks in the Induction Studies RPC01-3201 or RPC01-3202.
• Subjects who experience relapse or who complete the Maintenance Study RPC01-3203.
• Subjects who complete a study of ozanimod for Crohn's Disease and meet the criteria for participation in the RPC01-3204 Study will have the opportunity to participate in this study.

Exclusion Criteria:

Exclusions Related to General Health:

• Subject has any clinically relevant hepatic, neurological, pulmonary, ophthalmological, endocrine, psychiatric, or other major systemic disease making implementation of the protocol or interpretation of the study difficult or that would put the subject at risk by participating in the study.
• Subject is pregnant, lactating, or has a positive urine beta human chorionic gonadotropin (β-hCG).
• Subject has suspected or diagnosed intra-abdominal or perianal abscess that has not been appropriately treated.

Exclusions Related to Medications:

• Hypersensitivity to active ingredients or excipients of ozanimod.
• Subject has received any of the following therapies since the first dose of IP in the prior ozanimod study:
  • treatment with a biologic agent as well as other treatments for CD such as etrasimod, filgotinib, upadacitinib;
  • treatment with an investigational agent other than ozanimod;
  • treatment with D-penicillamine, leflunomide, thalidomide, natalizumab, fingolimod or other S1P modulators;
  • treatment with lymphocyte-depleting therapies (e.g., Campath®, anti-CD4, cladribine, rituximab, ocrelizumab, cyclophosphamide, mitoxantrone, total body irradiation, bone marrow transplantation, alemtuzumab, daclizumab).
• Subject is currently receiving or requires initiation of any of the following therapies:
  • treatment with corticosteroids at a dose that exceeds the prednisone equivalent of >40 mg;
  • treatment with immunomodulatory agents (e.g., azathioprine, 6-MP, or methotrexate)
  • chronic non-steroidal anti-inflammatory drug (NSAID) use (note: occasional use of NSAIDs and acetaminophen [e.g., headache, arthritis, myalgias, or menstrual cramps] and aspirin up to 325 mg/day is permitted);
  • treatment with Class Ia or Class III anti-arrhythmic drugs or treatment with 2 or more agents in combination known to prolong PR interval;
  • treatment with breast cancer resistance protein (BCRP) inhibitors (e.g., cyclosporine, eltrombopag).
• Subject is receiving treatment with any of the following drugs or interventions within the corresponding timeframe:
  • CYP2C8 inhibitors (eg, gemfibrozil or clopidogrel) and inducers (eg, rifampicin);
  • Monoamine oxidase inhibitors (eg, selegiline, phenelzine).

Exclusions Related to Laboratory Results:

• Subject has any clinically significant abnormality ECG results which in the opinion of the investigator may put the subject at risk.