Inclusion Criteria:

• Must have a documented diagnosis of CD confirmed by endoscopic biopsy before resection or by tissue obtained at resection.
• Planned to undergo a laparoscopic ileocecal resection with primary anastomosis within 72 hours before randomization Day 1. Confirmation that no active disease has been left behind after resection will be based on surgeon's documentation in the operative report.
• With postoperative discontinuation of all concomitant medications specifically related to the treatment of CD. This includes anti-tumor necrosis factor-alpha (TNF-α) and anti-integrin therapy, anti- interleukin (IL) 12/23, thiopurines and other immunomodulators, steroids, 5-minosalicylates, and prophylactic use of antibiotics for the prevention of postoperative recurrence such as metronidazole.
• Has resumed oral intake and is capable of swallowing tablets after surgery.

Exclusion Criteria:

• Has active perianal CD.
• Has had > 3 previous surgical procedures for CD.
• Has macroscopically active CD that was not resected at the time of surgery as documented in the surgeon's operative report.
• With small bowel resection that exceeds 100 centimeter (cm) or a participant who is considered at risk of short bowel syndrome by the surgeon or investigator.
• Has active or latent tuberculosis, regardless of treatment history, as evidenced by any of the following:
  • history of tuberculosis; OR
  • positive QuantiFERON test or 2 successive indeterminate QuantiFERON tests; OR
  • a tuberculin skin test reaction ≥ 10 millimeter (mm) (≥ 5 mm in participants receiving the equivalent of >15 milligram per day (mg/day) prednisone).
• Has chronic hepatitis B (hepatitis B surface antigen positive, or positive for both hepatitis B surface antibody and hepatitis B core antibody but negative for hepatitis B surface antigen) or hepatitis C infection (evident by viral replication by polymerase chain reaction) within 30 days of randomization.