Inclusion Criteria:

• 18 years of age and older.
• Life expectancy of ≥ 3 months.
• Histological/cytological diagnosis of de novo adenocarcinoma of the pancreas.
• Unresectable, locally advanced stage disease according to the following criteria:
• Head/uncinate process:
  • Solid tumor contact with SMA > 180°;
  • Solid tumor contact with the CA > 180°;
  • Solid tumor contact with the first jejunal SMA branch;
• Unreconstructible SMV/PV due to tumor involvement or occlusion (can be d/t tumor or bland thrombus).
• Contact with most proximal draining jejunal branch into SMV.
• Body and tail:
  • Solid tumor contact of > 180° with the SMA or CA;
  • Solid tumor contact with the CA and aortic involvement;
  • Unreconstructible SMV/PV due to tumor involvement or occlusion (can be d/t tumor or bland thrombus).
• No distant metastasis, including non-regional lymph node metastasis.
• No borderline resectable (per Al-Hawary MM, et al., Radiology 201414).
• ECOG score 0-2.
• Amenable and assigned by the investigator to receive therapy with gemcitabine and nab-paclitaxel.
• Able to operate the NovoTTF-100L(P) System independently or with the help of a caregiver.
• Signed informed consent form for the study protocol.

Exclusion Criteria:

• Prior palliative treatment (e.g. surgery, radiation) to the tumor
• Cancer requiring anti-tumor treatment within the 5 years before inclusion, excluding treated stage I prostate cancer, in situ cervical or uterus cancer, in situ breast cancer and non-melanomatous skin cancer.
• Serious co-morbidities:
• Clinically significant (as determined by the investigator) hematological, hepatic and renal dysfunction, defined as:
  • Neutrophil count < 1.5 x 10^9/L and platelet count < 100 x 10^9/L;
  • Bilirubin > 1.5 x Upper Limit of Normal (ULN); AST and/or ALT > 2.5 x ULN; and
  • Serum creatinine > 1.5 x ULN.
• History of significant cardiovascular disease unless the disease is well controlled. Significant cardiac disease includes second/third degree heart block; significant ischemic heart disease; poorly controlled hypertension; congestive heart failure of the New York Heart Association (NYHA) Class II or worse (slight limitation of physical activity; comfortable at rest, but ordinary activity results in fatigue, palpitation or dyspnea).
• History of arrhythmia that is symptomatic or requires treatment. Patients with atrial fibrillation or flutter controlled by medication are not excluded from participation in the trial.
• History of cerebrovascular accident (CVA) within 6 months prior to randomization or that is not stable.
• Active infection or serious underlying medical condition that would impair the ability of the patient to receive protocol therapy.
• History of any psychiatric condition that might impair patient's ability to understand or comply with the requirements of the study or to provide consent.
• Concurrent anti-tumor therapy beyond gemcitabine and nab-paclitaxel
• Implantable electronic medical devices in the torso, such as pacemakers
• Known severe hypersensitivities to medical adhesives or hydrogel, or to one of the chemotherapies used in this trial.
• Pregnancy or breast-feeding (female patients with reproductive potential and their partners must accept to use effective contraception throughout the entire study period and for 3 months after the end of treatment). All patients who are capable of becoming pregnant must take a pregnancy test which is negative within 72 hours before beginning treatment. The definition of effective contraception is left up to the decision of the investigator.
• Unable to follow the protocol for medical, psychological, familial, geographic or other reasons.
• Admitted to an institution by administrative or court order.