Inclusion Criteria:

- Participants must meet the following criteria on screening examination to be eligible
to participate in the study. Laboratory assessments for eligibility must be completed
within 14 days prior to the date of registration. Diagnostic imaging, such as MRIs and
CT scans, must be performed within 28 days of the planned treatment start.

- Participants must have histologically or cytologically confirmed invasive breast
cancer Stage I to III with primary tumor size at least 1.5 cm defined by physical exam
or imaging (whichever is larger). In the case of a multifocal, multicentric, or
bilateral disease, the largest lesion must be ≥ 1.5 cm and designated as the "index"
lesion for tumor evaluations. Patients with inflammatory breast carcinoma are not
eligible.

- Participants must have documentation of estrogen receptor (ER) and progesterone
receptor (PR) testing by IHC according to local institutional guidelines in a
CLIA-approved setting. Central confirmation of ER/PR status is not required. All
tumors must be HER2 negative.

- Arms A and B: Target lesion must be ER and PR negative (<10% staining) by local
review.

- Arm C: Target lesion must be ER and/or PR positive (>10% staining) by local
review.

- Participants must have documented HER2-negative invasive tumor according to local
institutional guidelines in a CLIA-approved setting. Central confirmation of HER2
status is not required. HER2 negative is defined as:

- 0 or 1+ by IHC, OR

- Lack of gene amplification with HER2/CEP17 ratio < 2 by ISH, OR

- Copy number < 6 by ISH

- Participants must have documented germline mutation in BRCA1, BRCA2 or PALB2 that is
deleterious or suspected to be deleterious (known or predicted to be detrimental/lead
to loss of function). Mutation must be identified through a CLIA-approved laboratory.
Final determination of eligibility for any discordant results in pathogenicity will be
made by the sponsor-investigator. A formal eligibility exception will not be required
in these cases as long as approval by overall study PI is granted and documented.

- Participants with multifocal, multicentric or bilateral disease are eligible if at
least one lesion meets criteria for the study. In this circumstance, the investigator
must determine which will represent the target lesion to be assessed for response.
This should remain consistent throughout the study. The target lesion should be
selected on the basis of its size (lesion with the longest diameter) and suitability
for accurate repetitive measurements.

- Participants with an eligible target lesion, and another small HER2+ tumor (for
example, < 6 mm), may be eligible for enrollment following discussion and agreement
with the overall principal investigator. A formal eligibility exception will not be
required in these cases as long as approval by the sponsor-investigator is granted and
documented.

- Female or male ≥ 18 years of age

- Breast imaging should include imaging of the ipsilateral axilla. For subjects with a
clinically positive axilla by physical examination or imaging, axillary tissue
acquisition is not required. For patients with a clinically negative axilla by
examination and imaging, tissue acquisition is not required. For equivocal imaging
findings, tissue acquisition (a needle aspiration, core biopsy) is required. Sentinel
Lymph Node (SLN) biopsy before neoadjuvant therapy is not allowed.

- ECOG performance status of 0 or 1

- Adequate organ and bone marrow function as defined below:

- Absolute neutrophil count (ANC) ≥ 1500/mm3

- Platelet count ≥ 100,000/mm3

- Hemoglobin ≥ 9 g/dl

- Total serum bilirubin ≤ 1.5 × institutional upper limit of normal (ULN), (≤2.0 in
patients with documented Gilbert's Syndrome)

- AST (SGOT) and ALT (SGPT) ≤ 2.5 × institutional ULN

- Serum or plasma creatinine ≤ 1.5 × institutional ULN, OR calculated creatinine
clearance > 50 mL/min using the Cockcroft-Gault equation

- International normalized ratio (INR) OR prothrombin time (PT) ≤1.5× ULN.
Participants who are receiving anticoagulant therapy are eligible as long as PT
or partial thromboplastin (PTT) is within therapeutic range of intended use of
anticoagulants. Activated partial thromboplastin time (aPTT) must be ≤1.5× ULN
unless patient is receiving anticoagulant therapy as long as PT or PTT is within
therapeutic range of intended use of anticoagulants

- Premenopausal women must have a negative urine or serum pregnancy test within 7 days
of treatment start. Women are considered non-childbearing (by other than medical
reasons) if they:

- are ≥45 years of age and without menses for >1 year

- have been amenorrhoeic for <2 years without history of a hysterectomy and
oophorectomy with a follicle stimulating hormone value in the postmenopausal
range upon screening evaluation

- are post-hysterectomy, post-bilateral oophorectomy, or post-tubal ligation.
Documented hysterectomy or oophorectomy must be confirmed with medical records of
the actual procedure or confirmed by an ultrasound. Tubal ligation must be
confirmed with medical records of the actual procedure, otherwise the patient
must be willing to use an adequate barrier method throughout the study, starting
with the screening visit through 180 days after the last dose of study treatment.
See list of acceptable birth control methods. Information must be captured
appropriately within the site's source documents. Note: Abstinence is acceptable
if this is the established and preferred contraception for the patient.

- Male and female participants of childbearing potential must agree to adhere to
adequate contraception as defined in the protocol for the duration of study
participation and for 150 days after the last dose of study treatment.

- Female participants must agree to not breastfeed during the study or for 150 days
after the last dose of study treatment.

- Participants must agree to not donate blood during the study or for 90 days after the
last dose of study treatment.

- Ability to understand and willingness to sign an informed consent document.

- Ability to swallow and retain oral medication.

- Patients undergoing breast conserving therapy (ie lumpectomy) should not have any
contraindications to radiation therapy.

- Participants must be willing to undergo the mandatory research biopsy at baseline and
after 3 weeks on study treatment. Participants who undergo an attempted research
biopsy procedure for the purpose of this protocol and in whom inadequate tissue is
obtained are not required to undergo a repeat biopsy in order to continue on the
protocol.

Exclusion Criteria:

- Stage IV breast cancer.

- Concurrent therapy with any other investigational product

- Prior treatment for the current breast cancer, including prior chemotherapy, immune
therapy, hormonal therapy, radiation, or investigational therapy for this diagnosis.

- Excisional biopsy of the primary tumor and/or excision of axillary lymph nodes,
including SLNB, prior to study treatment.

- Participants with a history of malignancy are ineligible except in the following
circumstances:

- Individuals with a history of invasive breast cancer are not eligible unless they
have been disease-free for a minimum of three years.

- Individuals with a malignancy history other than invasive breast cancer are
eligible if they have no active malignancy and are deemed by the investigator to
be at low risk for recurrence of that malignancy.

- Individuals with the following cancer history are eligible: adequately treated
nonmelanoma skin cancers, curatively treated in situ cancer of the cervix, ductal
carcinoma in situ (DCIS) of the breast, stage 1 grade 1 endometrial carcinoma.

- Other exceptions may exist following agreement with the sponsor-investigator

- Patients with a diagnosis of immunodeficiency, or currently receiving systemic steroid
therapy or any other form of immunosuppressive within 7 days prior to the first dose
of study treatment. Use of local corticosteroid injections (e.g. intraarticular
injections), inhaled, intranasal, ophthalmic, and topical corticosteroids, and
subjects requiring corticosteroid pre-medication for hypersensitivity reactions (e.g.

CT scan pre-medication) are allowed.

- Patients with autoimmune disease that has required systemic treatment within the past
2 years (i.e. with use of disease-modifying agents, corticosteroids, or
immunosuppressive drugs). Replacement therapy (e.g. thyroxine, insulin, or physiologic
corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is
not considered a form of systemic treatment.

- Patients with a history of interstitial lung disease or pneumonitis.

- Patients who have received a live vaccine within 2 weeks prior to the start of study
treatment.

- Patients who have undergone any major surgery within 3 weeks prior to study entry:

patients must have recovered to baseline from any effects of any major surgery.

- Patients with concurrent HIV infection are eligible provided they meet the following
criteria:

- CD4+ T-cell (CD4+) counts ≥ 350 cells/uL

- No history of AIDS-defining opportunistic infection within 12 months prior to
enrollment

- Any medication used in an antiretroviral therapy (ART) regimen must have no known
interaction with the study agents

- Patients with active or chronic Hepatitis B or C are eligible provided they meet the
liver function laboratory criteria described in 3.1.10 and cannot be on any medication
with a known interaction with the study agents

- Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
arrhythmia, recent (within 90 days) myocardial infarction, uncontrolled major seizure
disorder, unstable spinal cord compression, superior vena cava syndrome or psychiatric
illness/social situations that would limit compliance with study requirements.

- History of allergic reactions attributed to compounds of similar chemical or biologic
composition to niraparib, dostarlimab, or their excipients.

- Transfusion (platelets or red blood cells) ≤ 4 weeks prior to initiating protocol
therapy.

- Known history of myelodysplastic syndrome (MDS) or or acute myeloid leukemia (AML).

Note: Other protocol defined Inclusion/Exclusion criteria may apply.

Eligibility last updated 5/16/23. Questions regarding updates should be directed to the study team contact.