Inclusion Criteria:

• Patients with scleroderma meeting either a, b, c, or d:
• the 2013 ACR criteria;
• 3 out of 5 CREST (calcinosis, Raynauds, esophageal dysmotility, sclerodactyly, telangiectasias);
• triad of Raynauds, nailfold capillary abnormalities, and positive scleroderma autoantibody;
• very early diagnosis of systemic sclerosis (VEDOSS) defined as Raynaud’s, puffy digits, and abnormal nailfold capillaries or positive autoantibody.
• Patients with overlapping autoimmune phenotypes may be included, provided they meet the 2013 scleroderma classification criteria (a).
• This protocol will also allow for recruitment of healthy volunteers for comparison studies.

Exclusion Criteria: 

• Patients without scleroderma will be excluded from the primary disease cohort.
• Healthy volunteers (for the comparison cohort) will excluded if they have any autoimmune condition(s) (rheumatic, neurologic, hematologic, etc., at the discretion of the primary investigator or co-investigators).

Eligibility last updated 12/6/21.  Questions regarding updates should be directed to the study team contact.