Inclusion Criteria:

- Male or female and ≥18 years-of-age at the time of signature of the informed consent

- Confirmed advanced solid tumors resistant or refractory to standard treatment

- Eastern Cooperative Oncology Group (ECOG) Performance Status score of 0 or 1.

- All patients must have locally advanced or metastatic CRC, GI, or esophageal cancer(s)
and radiographic evidence of progressing disease.

- Measurable disease as per RECIST v1.1

- Submission of available tumor tissue or willingness to have a biopsy performed if safe
and feasible

- Acceptable hematologic and organ function at screening

- Negative pregnancy test for women of childbearing potential at Screening and prior to
first study drug.

Exclusion Criteria:

- Inability to swallow and retain oral medications.

- Chemotherapy or small molecule antineoplastic agent given within 21 days or <5 half-
lives, whichever is shorter, prior to first dose of study treatment.

- History or current condition, therapy, or laboratory abnormality that might confound
the study results, or interfere with the patient's participation for the full duration
of the study treatment.

- Patients who are pregnant or breastfeeding

- Life-threatening illness, medical condition, active uncontrolled infection, or organ
system dysfunction or other reasons which, in the investigator's opinion, could
compromise the participating patient's safety.

- Major surgery within 4 weeks prior to first study treatment dose.

- Uncontrolled, symptomatic brain metastases.

- Uncontrolled high blood pressure

- Active, uncontrolled bacterial, fungal, or viral infection, including hepatitis B
virus (HBV), hepatitis C virus (HCV), known human immunodeficiency virus (HIV), or
acquired immunodeficiency syndrome (AIDS) related illness.

- Moderate or severe hepatic impairment

- Cardiac diseases currently or within the last 6 months as defined by New York Heart
Association (NYHA) ≥Class 2

- Psychological, familial, sociological, or geographical conditions that do not permit
compliance with the protocol and/or follow-up procedures outlined in the protocol.