Recognition by Metabolomic Analysis of Serum of Hepatocellular Carcinoma

Overview

About this study

The purpose of this study is to validate an NMR-based (Nuclear magnetic resonance) serum metabolite constellation for detection of early Hepatocellular carcinoma (HCC) lesions in liver cirrhosis.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Liver cirrhosis of any etiology. Diagnosis of cirrhosis based on at least one of the following criteria:
    • Histology;
    • Imaging showing cirrhotic liver;
    • Elastography indicating cirrhosis
    • FibroTest result of F4;
    • Varices AND chronic liver disease;
    • Ascites AND chronic liver disease.
  • Patient is scheduled for HCC surveillance according to standard of care (SOC) using abdominal ultrasound (US) and blood-based liver function tests (LFT).
  • Age ≥ 18 years.
  • Patient information received, read, understood, and signed.

Exclusion Criteria:

  • History of liver cancer.
  • History of any other cancer.
  • History of liver resection.
  • History of solid organ transplant.
  • Liver fibrosis < F4.
  • Life expectancy is < 12 months.

Eligibility last updated 6/6/22. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Lewis Roberts, M.B., Ch.B., Ph.D.

Open for enrollment

Contact information:

Natalie Kyek PMP

(507) 266-3987

Kyek.Natalie@mayo.edu

More information

Publications

Publications are currently not available

Additional contact information

Cancer-related trials contact form

Phone: 855-776-0015 (toll-free)

International patient clinical studies questions