Imaging of Systemic Light Chain Cardiac Amyloidosis and Whole-Body Amyloidosis
Overview
Tab Title Description
Study type
InterventionalDescribes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study IDs
Site IRB
- Jacksonville, Florida: 22-000650
About this study
The objective of our study is to develop [11C]PIB PET as a new imaging biomarker for quantitative assessment of AL cardiac amyloidosis. The hypothesis is the degree of amyloid deposition in the myocardium and other organs in whole body could be detected and quantified by [11C]PIB PET imaging, which will diagnose cardiac amyloidosis early, differentiate AL cardiac amyloidosis from others, and monitor therapy response.
Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria:
- Patients with diagnosis of light-chain (AL) or transthyretin-related (TTR) cardiac amyloidosis will be included in the study.
- Males and females over the age of 18 years.
- Women of childbearing potential with a negative urine pregnancy test.
Exclusion Criteria:
- Males and females under the age of 18 years.
- Pregnant subjects will be excluded from the study.
- Participants that are unable to sign consent forms.
- Patient with claustrophobia who cannot tolerate PET/CT procedure.
- Patients with intracardiac leads or devices.
Eligibility last updated 9/1/22. Questions regarding updates should be directed to the study team contact.
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
| Mayo Clinic Location |
Status |
|
Jacksonville, Fla.
Mayo Clinic principal investigator Manoj Jain, M.D. |
Closed for enrollment |
|
More information
Publications
Publications are currently not available