Inclusion Criteria:

1. Presentation with a new diagnosis of peripartum cardiomyopathy

2. Post-delivery and within the first 5 months post-partum.

3. Clinical assessment of an LVEF < or =0.40 within 4 weeks of consent for randomized
control trial

4. Clinical assessment of an LVEF < or =0.40 within 8 weeks of consent for breastfeeding
cohort

5. Age > or = 18.

Exclusion Criteria:

1. Previous diagnosis of cardiomyopathy, valvular disease or congenital heart disease
(with the exception of women with a history of peripartum cardiomyopathy with complete
recovery and a documented LVEF > 0.55 prior to or in early pregnancy)

2. Refractory hypertension (Systolic >160 or Diastolic > 95) either at the time of
enrollment or at the time of the qualifying LVEF.

3. Postpartum women currently breastfeeding and planning to continue.

4. Evidence of coronary artery disease (>50% stenosis of major epicardial vessel or
positive non-invasive stress test)

5. Previous cardiac transplant

6. Current durable LVAD support

7. Currently requiring support with extracorporeal membrane oxygenation (ECMO)

8. Current history of alcohol or drug abuse

9. Chemotherapy or chest radiation within 5 years of enrollment

10. Evidence of ongoing bacterial septicemia

11. Medical, social or psychiatric condition which limit the ability to comply with
follow-up.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 2/27/2024. Questions regarding updates should be directed to the study team contact.