Inclusion Criteria:          

• Two groups of adults will be tracked:
  • Adults who do not have chronic pain (control group); and
  • Adults who have had fibromyalgia greater than 6 months. The groups will be matched for age, body mass index, and sex.
• Men and women, 18-80 years of age.
• Non-obese class III (body mass index BMI ≤ 39.9 kg/m^2).

Exclusion Criteria: 

• Body mass index greater or equal to 40 kg/m^2.
• Current nicotine use (e.g., smoking, chewing tobacco, vaping, etc.).
• Significant metabolic (e.g., diabetes), cardiovascular (including stage II hypertension) or neurologic disease.
• Known skin allergies or disease, disorders of pigmentation, or rash; history of angioedema.
• Renal disease, renal artery stenosis, and/or renal impairment.
• Any current medications which could conceivably alter cardiovascular responses (e.g. antihypertension medication, diuretic, digoxin, CYP3A4 inhibitors, Lithium, etc.).
• Taking hormone replacement therapy.
• Women who are pregnant or breastfeeding.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 7/19/23. Questions regarding updates should be directed to the study team contact.