A Study of Autoimmune Disease Mutations IKZF1 and UBR4

Overview

About this study

The purpose of this study is to identify immune mechanism how IKZF1 and UBR4 mutations cause disease. Understanding of the functional implications of these gene mutations will allow the development of a better disease model that could also be relevant for non-familial disease and allow more targeted treatment.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Individuals identified to carry one or both mutations.
  • Patients with diagnosed IgG4 disease or related disease.
  • Healthy control individuals of different ages and both genders.

Exclusion Criteria:

  • History of chemotherapy for malignancies.
  • Acute infectious disease.
  • Pregnancy.

Eligibility last updated 7/27/22. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Jorg Goronzy, M.D., Ph.D.

Open for enrollment

Contact information:

Patricia Kennedy

(507) 266-1986

Kennedy.Patricia1@mayo.edu

More information

Publications

Publications are currently not available