Differences in Blood Cell Types in Peripheral Arterial Disease and Healthy Subjects

Overview

About this study

The purpose of this study is to investige if there are differences in blood cell types between patients with peripheral arterial disease (PAD) and healthy subjects of similar ages.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria - PAD Patients:

  • Mild claudication to minor tissue loss (Rutherford 1-5).
  • Resting or exercise ankle-brachial index < 0.9 or toe brachial index < 0.6.
  • Age 35 or more.

Inclusion Criteria - Healthy Volunteers:

  • Age 35-90.

Exclusion Criteria - PAD Patients and Healthy Volunteers: 

  • Evidence of active infection.
  • Chronic liver disease, end-stage renal disease (CKD 5), or chronic inflammatory disease.
  • Poorly controlled diabetes (HbA1c > 8%).
  • BMI < 18 or > 35.
  • Recent other major surgery or illness within 30 days.
  • Use of immunosuppresive medications or steroids.
  • History of organ transplantation.
  • Pregnancy, or plans to become pregnant, or lactating.

Exclusion Criteria - Healthy Volunteers:

  • hsCRP > 2 mg/L.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 5/19/23. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Melinda Schaller, M.D.

Open for enrollment

Contact information:

Sonja Riggs

(507) 266-3161

Riggs.Sonja@mayo.edu

More information

Publications

Publications are currently not available