Inclusion Criteria:

Eligible participants must include all of the following:

• Be a Master Athlete:
  • Is ≥ 35 years old;
  • Currently (or who has previously) systematically training for competitive and/or mass participation sporting events;
  • Recent history of participation in competitive and/or mass participation event (e.g., 1 or 2 per year for past 5 years); AND
  • Current training includes ≥ 4 exercise sessions per week for a total duration of ≥ 150 minutes per week;
  • Has evidence of trivial, mild, or moderate (< 70%) coronary stenosis on cardiac CT scan within 12 months prior to enrollment;
  • Actively participates in moderate to high intensity athletics for at least 100 minutes per week.

Exclusion Criteria:

Exclusion criteria include the following:

• Greater than 50% left main coronary artery disease on cardiac CT scan.
• Inability to exercise and/or perform resistance exercise.
• Currently on antihypertensive therapy.
• Family or Personal History of Sudden Cardiac Death.
• Has clinical angina or heart failure.
• Positive for pregnancy.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 9/6/23. Questions regarding updates should be directed to the study team contact.