QuickSIN for Central Auditory Processing Disorder in Patients with Normal Hearing Sensitivity and Reported Speech-in-Noise Difficulty

Overview

About this study

The purpose of this study is to whether the QuickSIN with 0.3 sec reverberation time is a better method than the standard (no reverberation) QuickSIN of detecting central auditory processing disorder (CAPD) in individuals who undergo CAPD evaluations and are diagnosed with CAPD. Also, whether the QuickSIN with 0.3 sec reverberation time is a better method than the standard (no reverberation) QuickSIN at correctly identifying individuals who do not receive a CAPD diagnosis.

 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Normal otoscopic visualization of both ears, including clear external auditory canals and visible tympanic membranes and associated landmarks (e.g., cone-of-light, long arm of manubrium, etc.).
  • Normal pure-tone hearing sensitivity (25 dB HL or better) across all octave frequencies (250 Hz through 8000 Hz) as well as for interoctave frequencies.
  • Tympanometry within normal limits for middle ear pressure (+100 through -150 daPa), tympanic membrane compliance (0.3 through 1.7 mmho), and ear canal volume (0.2 through 2.0 ml), qualified as Jerger Type A tympanograms, in both ears.
  • Ipsilateral and contralateral acoustic reflex threshold patterns that do not indicate the presence of auditory neuropathy spectrum disorder (ANSD). A pattern consistent with ANSD would be elevated and/or absent acoustic reflex thresholds across all conditions and test frequencies in both ears.
  • Present distortion-product otoacoustic emissions (DPOAE) from 1000 Hz through 8000 Hz, bilaterally.

Exclusion Criteria: 

  • Abnormal appearance of one or both external auditory canal(s) and/or tympanic membrane(s) on otoscopic examination.
  • Presence of any degree (mild, moderate, moderately severe, severe, or profound), type (conductive, sensorineural, or mixed), and configuration (shape) of hearing loss.
  • Tympanometry in one or both ears that is abnormal for middle ear pressure (exceeding either +100 or -150 daPa), tympanic membrane compliance (below 0.3 or above 1.7 mmho), and/or ear canal volume (less than 0.2 or greater than 2.0 ml). This includes tympanograms described as As, Ad, B, and C.
  • Ipsilateral and contralateral acoustic reflex threshold patterns that indicate the presence of ANSD (i.e., elevated and/or absent acoustic reflex thresholds across all conditions and test frequencies in both ears).
  • Absent DPOAEs for any frequency measured between 1000 Hz through 8000 Hz for either ear.

Note: Other protocol defined Inclusion/Exclusion criteria may apply.

Eligibility last updated 3/14/23. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Jennifer Gonzalez, Au.D., Ph.D.

Open for enrollment

Contact information:

Jennifer Gonzalez Au.D., Ph.D.

Gonzalez.Jennifer@mayo.edu

More information

Publications

Publications are currently not available