A Study of JNJ-90009530 in Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma (r/​r B-NHL)

Overview

About this study

The goal of this multicenter study is to test JNJ-90009530 in Relapsed or Refractory Non-Hodgkin Lymphoma Patients. The main questions the study aims to answer are:  -can a safe dose of JNJ-90009530 be determined that is safe and well tolerated by  patients.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Participant must be ≥ 18 years of age at the time of  signing informed consent.
  • Diagnosis of mature aggressive large B cell non-Hodgkin lymphoma or Follicular  lymphoma Grade 3B.
  • Tumor must be cluster of differentiation (CD) 20 positive by immunohistochemistry.
  • Have relapsed or refractory disease after ≥ 2 lines of standard therapy and relapsed within 12 months of last therapy.
  • Measurable disease as defined by Lugano 2014 classification.
  • Eastern Cooperative Oncology Group (ECOG) performance status of either 0 or 1.

Exclusion Criteria: 

  • Diagnosis of Human herpes virus (HHV) 8-positive Diffuse large B Cell lymphoma (DLBCL).
  • Prior allogeneic Hematopoietic stem cell transplantation (HSCT).
  • Autologous stem cell transplant within 12 weeks of chimeric antigen receptor (CAR) T- cell infusion.
  • Uncontrolled active infections.
  • History of deep vein thrombosis or pulmonary embolism within six months of infusion (except for line associated deep vein thrombosis [DVT]).
  • History of stroke, unstable angina, myocardial infarction, congestive heart failure (New York Heart Association [NYHA] Class III or IV), severe cardiomyopathy or ventricular arrhythmia requiring medication or mechanical control within 6 months of  screening.
  • History of a seizure disorder, cerebrovascular ischemia/hemorrhage, dementia,  cerebellar disease or neurodegenerative disorder.
  • Known history or prior diagnosis of optic neuritis or other immunologic or  inflammatory disease affecting the central nervous system.
  • Active central nervous system (CNS) involvement by malignancy.
  • Current active liver or biliary disease (except for Gilbert's syndrome or asymptomatic gallstones).

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 8/23/23. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Yi Lin, M.D., Ph.D.

Open for enrollment

Contact information:

Cancer Center Clinical Trials Referral Office

(855) 776-0015

More information

Publications

Publications are currently not available