Oral and Intravenous Methadone for Analgesia in Cardiac Surgery

Overview

About this study

The purpose of this study is to compare the effects of administration of oral methadone preoperatively and intravenous methadone after induction of general anesthesia on postoperative pain for patients undergoing elective cardiac surgery. 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • >= 18 years of age, undergoing elective cardiac surgery as the first case of the day in an operating room

Exclusion Criteria: 

  • Chronic pain requiring opioid medications as an outpatient, opioid use disorder on medication assistance treatment, prolonged QTc >500ms, chronic kidney disease with eGFR < 30mL/min, documented cirrhosis, intolerance to methadone, subsequent surgeries after index surgery

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 07/15/2024. Questions regarding updates should be directed to the study team contact.

 

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Krishnan Ramanujan, M.D.

Contact us for the latest status

Contact information:

Krishnan Ramanujan M.D.

(507) 422-0662

Ramanujan.Krishnan@mayo.edu

More information

Publications

Publications are currently not available