Inclusion Criteria:

• Age 40-55 years old.
• Female individuals with intact uterus and at least one ovary.
• Currently in the menopause transition:
  • Defined as self-reported bleeding patterns encompassing the early and late perimenopause phases, in accordance with the Stages of Reproductive Aging Workshop (STRAW) Criteria:6 a difference of ≥7 days in the length of consecutive menstrual cycles which recurs within 10 cycles from the first occurrence (early menopause), or 2 to 12 months of amenorrhea (late perimenopause)
• Hypertension:
  • Defined as a prior diagnosis of hypertension, use of antihypertensive agents, or office SBP/DBP ≥ 130/80 mmHg
• On stable medical regimen (≥ 2months) if taking other medications.

Exclusion Criteria:

• Prescription sleeping medications or melatonin supplementation
• Pregnant or lactating
• Night shift work
• Current or recent (within the past 2 months) use of hormonal contraceptives
• Current or recent (within the past 2 months) use of hormone replacement therapy
• On prescription aspirin
• Severe lactose intolerance
• History of substance use disorder
• History of suicidal ideation
• History of clinically diagnosed anemia or low hemoglobin levels (<11.6 g/dL) within the past 12 months
• Active cancer
• Severe daytime sleepiness (score > 15 at the Epworth Sleepiness Scale [ESS])80
• Current or recent (within the past 2 months) participation in other research studies at the discretion of study investigators
• Inability to provide written consent and/or to speak and read English
• Any other medical, geographic, or social factor making study participation impractical

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 01/03/2025. Questions regarding updates should be directed to the study team contact.