Clinical Trials

The purpose of this study is to pilot test the ENHANCE intervention to evaluate methodology, feasibility based on caregiver input, and preliminary caregiver satisfaction. The primary outcomes will be feedback from parents, participant completion/atrition rates, the interventionist study log, and interventionist/caregiver/fidelity. Second, we aim to examine preliminary impact of the naturalistic intervention on child social communication and repetitive behavior in order to estimate clinically meaningful change for future research studies. 

The purpose of this study is to confirm a correlation between metal ion dyshomeostasis (low Zn levels, abnormal Zn/Cu ratio, or low Selenium levels) in a North American population and the diagnosis of ASD using gold standard diagnostic instruments.

Autism Spectrum Disorders (ASDs) are lifelong neurodevelopmental conditions with mostly unknown etiology that have a huge impact on affected individuals and their families, and are a major public health concern.  Significant gaps exist in the knowledge of ASD frequency and its possible rising trend.  Detailed characterization of ASD cases ASD subtypes is sparse, and potential risk factors (etiologies) are still unknown.  We will study certain risk factors like perinatal risk factors and family history (parents, siblings) of psychiatric disorders.  Knowledge about adult outcomes of ASD cases identified in childhood is almost non-existent.  ASD-associated medical costs are high, yet information to ...

The purpose of this study is to determine whether a group recreation intervention for six to eight year old children with autism, who have deficits in gross motor skills is feasible and acceptable. Additionally the study will explore whether a group recreation intervention can improve gross motor skills, social skills, physical activity, and reduce parent stress.

The purpose of this study is to screen mothers of young children with Autism Spectrum Disorders for metabolic problems, and find if it can be treated with a vitamin/mineral supplement with a different form of folic acid and more B12. These mothers will also be compared to the same number of mothers of normal children for the same metabolic markers.

This is an interview study to understand the views of people with the lived experience of 10 different genetic conditions on gene modification therapies, and specifically on prenatal gene editing. Prenatal gene editing is not happening now, but it is possible that prenatal gene editing will be available in the next few years, at least in a research setting, and we want to know your thoughts about the direction this technology is going. We to hope speak with many different stakeholders (patients and their families, clinicians, scientists) with diverse perspectives to understand values and priorities for prenatal gene ...