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SPI-62 as a Treatment for Hypercortisolism Related to a Benign Adrenal Tumor
Rochester, MN
The purpose of this study is to evaluate the effectiveness, safety, and pharmacological effect of SPI-62 in subjects with hypercortisolism related to a benign adrenal tumor.
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A Study of the Characteristics of Adrenal Steroid Production and Metabolism in Patients with Adrenal Tumors, Using Comprehensive Steroid Profiling
Rochester, MN
The purpose of this study is to characterize adrenal steroid synthesis and metabolism in patients with nonfunctioning adrenal tumors (NF), adrenal tumors with subclinical Cushing Syndrome (SCS) and Cushing Syndrome (CS). The study also aims to characterize altered metabolites and disruptive metabolic pathways, and to connect adrenalectomy-induced changes in β-cell function and insulin sensitivity with the preoperative metabolic profile in patients who have NF, SCS and CS adrenal tumors.
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Prospective Study of Adrenal Disorders: Clinical Registry, Imaging Analysis and Biomaterial Collection
Rochester, MN
The purpose of this research is to follow people with adrenal disorders in order to make conclusions about the natural history of a particular adrenal disease as well as effect of various therapies and interventions decided on by you and your medical team. In addition, we will collect biomaterial from you at times you are being evaluated which will be used to discover novel biomarkers which can potentially improve the accuracy of current diagnostic tests and affect the management of patients with adrenal disorders. We will also include a control group (without known adrenal disease) to compare to the volunteers ...