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Efficacy of Two Doses of Duloxetine and Amitriptyline in Subjects With Refractory Chronic Cough (MACS-1)
Rochester, MN
The purpose of this study is to evaluate the effectiveness of two escalating doses of Duloxetine & Amitriptyline in reducing awake objective cough frequency (at 4 & 8 weeks).
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A Study of the Self-Perception of Voice Disorders in Patients with Chronic Cough
Scottsdale/Phoenix, AZ
The purpose of this study is to measure the self-awareness of voice disorders in patients who have chronic cough, by comparing the results of patient self-report indicators with perceptual clinical rating.
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A Study to Assess the Effectiveness and Safety of AF-219 for Subjects with a Treatment Resistant Chronic Cough
Rochester, MN
The purpose of this study is to assess the effectiveness and safety of AF-219 given to subjects with a treatment resistant chronic cough.
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A Dose Escalation Study of BLU-5937 in Unexplained or Refractory Chronic Cough
Rochester, MN
The purpose of this study is to demonstrate the effectiveness and safety of multiple doses of BLU-5937 in adults suffering from RCC. The study will help determine the optimal BLU-5937 dose for Phase 3 studies.
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Evaluating the Safety, Tolerability and Effectiveness of ADX-629 t to Treat Chronic Cough
Rochester, MN
The purpose of this study is to evaluate the safety, tolerability, and effectiveness of ADX-629 300 mg administered orally BID for 14 days to approximately 50 adult subjects with refractory or unexplained chronic cough.
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Study to Assess the Effectiveness and Safety of Bradanicline in Patients with Chronic Cough
Rochester, MN
The purpose of this study is to evaluate the dose-response of bradanicline in reducing awake objective cough frequency.
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A Dose-ranging Study of Orvepitant in Patients With Chronic Refractory Cough
Rochester, MN; Jacksonville, FL
The purpose of this study is to determine the effectiveness of three doses of orvepitant, taken once a day, in the treatment of chronic refractory cough.
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A Study to Evaluate S-600918 in Adults With Refractory Chronic Cough
Rochester, MN
The primary objective of this study is to determine the optimal dose of S-600918 in patients with refractory chronic cough by evaluating the change from baseline in 24-hour cough frequency (coughs per hour) with S-600918 compared with placebo.
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Study of the Efficacy, Safety, and Tolerability of Serlopitant for the Treatment of Refractory Chronic Cough
Rochester, MN
Study of the efficacy, safety, and tolerability of serlopitant for the treatment of refractory chronic cough.
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Study to Evaluate the Efficacy and Safety of Gefapixant (MK-7264) in Adult Participants with Chronic Cough
Rochester, MN
The purpose of this study is to evaluate the sasfety and effectiveness of MK-7264 in reducing cough frequency as measured over a 24-hour period.
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A Study of AF-219 in Subjects with Idiopathic Pulmonary Fibrosis with Persistent Cough
Rochester, MN
The purpose of this study is to assess the safety and effectiveness of AF-219 in patients with idiopathic pulmonary fibrosis with persistent cough.
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Efficacy and Safety Study of Orvepitant for Chronic Cough in Patients With Idiopathic Pulmonary Fibrosis
Rochester, MN
ORV-PF-01 is a two way, placebo controlled, cross-over study, to evaluate the effect of two doses of orvepitant on cough in patients with Idiopathic Pulmonary Fibrosis (IPF).
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A Study of Inhaled RVT-1601 for the Treatment of Persistent Cough in Idiopathic Pulmonary Fibrosis (IPF)
Rochester, MN
The purpose of this study is to evaluate Inhaled RVT-1601 (formerly, PA101B), a new inhalation formulation of cromolyn sodium delivered via the eFlow® Closed System (CS) nebulizer, for the treatment of persistent cough in patients with idiopathic pulmonary fibrosis (IPF).
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A Study to Evaluate RheOx Bronchial Rheoplasty System to Treat Chronic Bronchitis in Adults with COPD
Jacksonville, FL; Rochester, MN
The purpose of this study is to assess the safety and effectiveness of Bronchial Rheoplasty for the treatment of the symptoms of chronic bronchitis in adult COPD patients with moderate to severe chronic bronchitis.