Clinical Trials

The purpose of this study is to collect survey data from athletes, coaches and parents/guardians to assess their baseline knowledge regarding the definition of concussion and concussion risk factors, long term effects, and basic management.

Diagnostic and injury quantification measures will show significant differences between non-concussed and concussed athletes to aid in future treatment protocols.  Data from accelerometers and video footage will provide additional information to further characterize concussive injuries and support diagnostic and treatment protocols.

The purpose of this study is to determine if nicotinamide riboside (750 mg/day for 12 weeks) can affect the levels of NAD+ in the brain as measured by 31P MRS.

Visually Evoked Potentials (VEPs) are electrical potentials elicited from brief visual stimuli and recorded from the visual cortex with surface electrodes.  VEPs are an objective, reliable, and non-invasive method for evaluation of the functional integrity of the retina and early afferent visual pathways. The purpose of this study is to compare the VEPs generated from a standard clinical evoked potential system to those obtained from the Vivonics portable VEP system.

This proposal aims to describe the oculometric features present during King-Devick (K-D) testing for subjects who experienced sports-related concussion. The investigators aim to better describe the underlying oculomotor anomalies present in this cohort that lead to increased K-D test time. Understanding these anomalies will allow for better understanding of the effects of sports-related concussion and may provide a rapid and reliable metric for diagnosing concussion as well as monitoring long-term recovery.

The purpose of this study is to determine if anesthesia after concussion is associated with cognitive dysfunction, and if recent concussion is a patient safety risk in the perioperative period

The purpose of this study is to determine return to baseline (RTB) period after an elective craniotomy procedure using the ImPACT testing assessment.

The purpose of this study is to determine the sensitivity and specificity of an aid in assessment of concussion based on eye-tracking, in comparison to a clinical reference standard appropriate for the Emergency Department (ED).

This study will investigate sub-concussions, concussions, and pre-syncopal choking episodes in a number of fighters using King Devick Test (KDT). We will also explore the immediate and long term consequence on the KDT results after a concussion or a pre-syncope have occurred.

The goal of our study is to validate KDT in Mixed martial arts (MMA), to propose the adoption of the KDT in the State of Minnesota to detect immediate cognitive decline during the amateur and pro-fighting event.

The purpose of this study is the evaluation of new tools and strategies for the clinical assessment, management, and rehabilitation of concussions.

The purpose of this study is to further demonstrate the value of the components of our objective diagnosis and quantification of severity: the NeuroCatch quantified electroencephalogram, the King-Devick test, blood biomarkers, and metabolomics profiling. Wearable accelerometers (Triax SIM-G) and video footage will provide data to correlate concussive injuries with physical parameters and mechanisms of injury. Time on Ice tracking will allow for calculation of Individual Exposure Time (IET).

The specific aim of this project is to systematically and prospectively collect and collate data derived from the clinical care of concussion patients seen at Mayo Clinic Arizona.

The purpose of this study is to compare the use of the King-Devick concussion test in the traditional neutral (forward facing) position, to a 45 degree turn of the neck to the left and right.

The purpose of this study is evaluate changes in male and female athletes’ brains following concussion injury and recovery, and to see whether female athletes demonstrate a different pattern of recovery compared to male athletes.

The purpose of this study is to investigate the reliability of a mobile app to assess balance in athletes during a concussion assessment

The purpose of this study is to demonstrate the value of our objective diagnosis of concussion (ODC) components and to quantify severity. ODC components include: the NeuroCatch™ Platform [quantified electroencephalogram (qEEG)] developed by NeuroCatch Inc., the King-Devick Test (in association with Mayo Clinic) of rapid number naming, and blood biomarkers such as neurofilament light (NfL), neuron-specific enolase (NSE), and S100B.  Wearable accelerometers (Triax Technologies’ SIM-G, X2 Biosystems X Patch, and Prevent Biometrics’ Impact Monitor Mouthguard) and three camera video footage will also provide acceleration data to correlate to concussive injuries and mechanism of injury. Time on Ice tracking will allow for ...

The purpose of this study is to investigate whether recent, groundbreaking discoveries about key pathophysiologic processes that drive chronic dizziness in patients without traumatic brain injury (TBI9,10) are applicable to patients with post-mTBI vestibular disability. We expect the results of this project to have practical clinical and research applications, providing novel data for two future steps:

The study is a prospective, multi-center, non-randomized, open label observational study. The objective of this study is to compare the accuracy of the EyeBOX to a clinical diagnosis of abnormal ICP as determined by an external ventriculostomy drain (EVD) or ventriculostomy catheter.

The purpose of this study is to build on previous work, replicating the experimental protocol for subconcussive intervention with soccer headers, while adding EEG measurements and using modern machine learning (ML) techniques to create a highly accurate diagnostic algorithm.

The purpose of this study is to determine if there are changes in mild traumatic brain injury (mTBI) and/or repetitive head impacts (RHI) detectible with multiparametric MR Elastography (MRE). The hypothesis is that multiparametric MR Elastography will detect changes in the mechanical properties of human head tissues in patients following head traumas.

The purpose of this study is to identify mechanisms and predictors for the persistence of post-traumatic headache and methods to treat post-traumatic headache and prevent its persistence.

Concussion is a health issue impacting all athletes for which a clinical treatment protocol, other than rest, has not been established. The efficacy of such a treatment protocol relies heavily on an objective diagnosis and quantification of injury severity. We hypothesize our chosen objective diagnostic and injury quantification measures will show significant differences between non-concussed and concussed athletes to aid in future treatment protocols. We also hypothesize that data from individual exposure time, video footage, and personality measures will provide additional information to further characterize concussive injuries and support diagnostic and treatment protocols.

This study aims to describe the oculometric features extracted during K-D testing using eye-tracking that are associated with concussions in a youth sports population.