Clinical Trials

The overall goal is to investigate the value of ultrasound imaging of tumor vasculature as a new biomarker for early treatment evaluation.

Multi-center, double-masked randomized, efficacy, safety and pharmacokinetic (PK) study.

The purpose of this study is to evaluate the effects of radiation on normal liver tissue. This will help us develop MRI-based dose range monitoring techniques for liver Stereotactic Body Radio Therapy.

Investigators are trying to learn more about why cavernous malformations form. In addition, investigators are trying to determine which cavernous malformations might cause future symptoms and which ones may be more benign. To do this, investigators are trying to look at various lifestyle factors, medication use, and other medical problems and how they influence what happens over time

This is a pilot study to investigate the performance of MR-guided Laser Induced Thermal Therapy (LITT) in the treatment of liver tumors.

This study is a prospective Phase IV study to determine if the use of Everolimus results in lower liver tumor recurrence and improved patient and graft survival after liver transplant for hepatocellular carcinoma (HCC). The immunosuppressive comparators will be Everolimus and Tacrolimus therapy compared to Tacrolimus and Mycophenolic acid/Mycophenolate Mofetil. Primary outcomes data is disease free survival (the time from randomization to HCC recurrence or death). Secondary outcomes are rate of recurrence of Hepatitis C, problems related to wound healing, hernia repair within the first 12 months, hepatic arterial thrombosis, renal function, acute cellular rejection, post-transplant diabetes, hypertension, and hyperlipidemia.

This protocol allows multiple treatments with TheraSphere® that may be delivered on an outpatient basis. Patients may receive a single dose to a liver lobe or segmental treatment delivered as a sequence of treatments approximately 30-90 days apart. The principal clinician, working with a multidisciplinary team, will develop a specific treatment plan for each patient, based upon the presenting condition of the patient, the vascular anatomy and the desired goal of treatment.

The purpose of this study is to assess the combined impact of post-processing methods that quantify potential biomarkers of chronic liver disease (AEF, fECS) and that improve iodine signal (vMono+) on detecting liver fibrosis and hepatic masses or esophageal varices, in comparison to routine contrast-enhanced liver CT.

The goal of the study is to identify immune responses (immune cell activation and suppression) following local ablation of liver tumors.

This study is being done to collect and store samples of blood from patients with liver disease for a research study to be able to find a new and better way to detect liver cancer.

The purpose of this study is to assess if using holography/ Augmented Reality and 3D-printed models to visualize intracranial diseases and aid in patient education.

The purpose of this study is to set up the infrastructure for future clinical trials for patients with cavernous malformations. To do this we will be assessing the quality of MRI and data collection from patients with cavernous malformations across multiple sites in the country. At Mayo, we will be looking at new MRI "sequences" in addition to the usual sequences to see if that helps determine which cavernous malformations may bleed again.

The purpose of this study is to develop prognostic and diagnostic blood tests for symptomatic brain hemorrhage in patients diagnosed with cavernous angiomas, a critical clinical challenge in a disease affecting more than a million Americans. We further examine whether blood biomarkers can replace or enhance the accuracy of advanced imaging in association with lesional bleeding. The project tests a novel integrational approach of biomarker development in a mechanistically defined cerebrovascular disease, with a clinically relevant context of use.