Clinical Trials

The purpose of this study is to:

1. To determine whether the presence of pleural effusion measured by bedside ultrasound in the immediate pre-liver transplant period is associated with worse postoperative outcome as compared to no pleural effusion
2. To determine the prevalence of pleural effusion in the immediate pre-liver transplant period measured by lung ultrasound, as compared to the prevalence measured by routine pre-transplant chest imaging

The purpose of this study is to evaluate treatment of persistent air leaks with the Spiration Valve System as compared to standard chest tube drainage management and other standard-of-care interventions.

The purpose of this study is to:

1. Evaluate MPM tumor heterogeneity by determining the agreement of histology, molecular abnormalities, neo-antigen expression and immunological biomarkers between three tumor samples from MPM patients.

2. Compare the information from tumor samples to pleural fluid, peripheral blood and density based radiomics analysis.

The primary objective of this proposal is to develop a Thoracic Specimen Registry at Mayo Clinic. The purpose of the registry will be to support ongoing research in the etiology, early diagnosis, clinical management, and prognosis of lung cancer and other cancers and diseases of the thorax by developing a complete repository of specimens from patients with thoracic disease including but not limited to suspected lung cancer, mediastinal and pleural tumors and from patients at a very high risk of developing other thoracic cancers or other thoracic diseases.