Clinical Trials

The purpose of this study is to validate the effectiveness of the ZephyrLife Home monitoring device compared with standard ICU or stepdown vital signs monitoring,  especially for heart rate, respiratory rate and temperature as systemic (whole body) inflammatory response syndrome or sepsis ( whole body infection) markers in stem cell transplant patients.

The SOFA score is a severity of illness and prognostic score used in the ICU. It has also recently been adopted as part of the definition of sepsis. This study will evaluate the usability of automated SOFA scoring for ICU patients within an electronic patient monitoring dashboard. It will also assess for changes in physician ordering (volume and types of orders) after automatic scoring is implemented.

This project aims to understand the risk factors for neonatal late-onset sepsis (LOS), a leading cause of death of preterm newborns. The majority of LOS is attributable to bloodstream infections.  Survivors have a significant risk of cognitive or developmental problems, highlighting the need for identification of preventive measures and interventions for bloodstream infections. We hypothesize that stool from LOS patients will contain reduced concentration of EGF, indicative of increased intestinal permeability.

The purpose of this study is to determine the accuracy and clinical usefulness of a physicians impression prior to having objective laboratory data or imaging results for the diagnosis of sepsis.

The investigators would like to determine if early administration of oral Midodrine in participants diagnosed with sepsis will impact blood pressures and decrease the need for and/or doses of intravenous pressor agents.

This research aims to demonstrate the benefits and risks of introducing in situ education into the NPPA work environment.

The purpose of this study is to assess the effectiveness and safety of oral rosuvastatin for the treatment of patients who have sepsis-induced acute lung injury.

The purpose of this study is to assess kidney microcirculation using contrast-enhanced ultrasonography associated with kidney ultrasound elastography among patients who are at risk of sepsis-associated acute kidney injury provides strong predictive ability for AKI and potential therapeutic targets. 

The purpose of this study is to determine whether the combination of Ascorbic Acid (Vitamin C), Thiamine (Vitamin B1), and Corticosteroids improves the trajectory of organ failure and reduces mortality in patients with sepsis and septic shock as compared to placebo.

The purpose of this study is to investigate the effectiveness of the combined use of vitamin C, thiamine and corticosteroids versus indistinguishable placebos for patients with sepsis. The objective of this study is to demonstrate the effectiveness of combination therapy using vitamin C, thiamine and corticosteroids in reducing mortality and improving organ function in critically ill patients with sepsis.

Severe acute respiratory failure requiring prolonged mechanical ventilation is the most common form of acute organ dysfunction in the hospital, and is often associated with multiple organ failure, high mortality, and functional impairment. The purpose of this study is to improve the outcomes of patients at high risk with early intervention using an electronic medical records checklist aimed at preventing the lung injury that commonly leads to organ failure.