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Sleep-disordered Breathing in Infants With Myelomeningocele
Rochester, MN
The purpose of this study is to determine whether the risk for sleep-disordered breathing in infants with myelomeningocele (a severe form of spina bifida) differs among those who underwent fetal vs. postnatal surgery, and to examine the link between sleep-disordered breathing and neurodevelopment.
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Screening for Sleep Disordered Breathing and Sleep Disturbance Among Patients Recovered from COVID Infection
Jacksonville, FL
The purpose of this study is to compare prevalence of sleep apnea and sleep disturbance in post-COVID-19 infected patients who had been symptomatic to COVID negative participants as controls. A sleep testing device will assess for sleep disordered breathing and the results will be aggregated to compare if a significant increase (any difference) in the prevalence of sleep disordered breathing diagnosis between the two groups. Sleep questionnares data will be obtained. A second part of this study will involve using a Fitbit consumer wearable device to obtain sleep and activity data on participants for 2 months in duration.
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Submandibular Gland Needle Core Biopsy and Skin Punch Biopsy as Tissue Biomarkers for the Diagnosis and Monitoring of Disease Progression of Parkinson’s Disease and REM Sleep Behavior Disorder
Scottsdale/Phoenix, AZ
Determine 1) the magnitude of SMG and skin a-syn density change over time, 2) the
improvement in adequate tissue acquisition doing bilateral SMG biopsies, 3) any laterality differences between
SMG gland a-syn density, 4) correlate a-syn density and changes in density between SMG and skin biopsies
Specific Aim 1. Determine, with bilateral submandibular gland (SMG) biopsies in 30 clinically
diagnosed subjects with Parkinson’s disease (PD) and 20 clinically probable REM sleep behavior
disorder (RBD) subjects whether bilateral biopsies improve the rate of acquisition of adequate
glandular tissue, whether alpha-synuclein (a-syn) SMG pathology ...
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Assessment of Sleep Disturbance and Sleep Disordered Breathing in Primary Immunodeficiency Disorders
Jacksonville, FL
The purpose of this research is to understand sleep disturbances in patients with primary immunodeficiency.
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Synucleinopathies
Rochester, MN
The goals of the study are to prospectively evaluate clinical and laboratory biomarkers of multiple system atrophy and Parkinson’s disease at early clinical disease, at a premotor stage (PAF), and even at a prodromal stage (RBD).
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A Study to Evaluate Comorbid Insomnia and Sleep Disordered Breathing in Patients Undergoing Cardiac Rehabilitation
Rochester, MN
The objectives of this study are to examine the prevalence of comorbid sleep disordered breathing (SDB) and insomnia in post-MI patients enrolled in cardiac rehabilitation (CR), to assess whether post-MI CR patients with comorbid SDB and insomnia exhibit a more unfavorable CV profile than those without, and to determine whether post-MI CR patients with comorbid SDB and insomnia show less adherence to CR than those without.