Clinical Trials

The purpose of this study is to evaluate the effectiveness of muscle-tendon lengthening procedures versus Hyperselective neurectomy (HSN) in decreasing elbow flexor spasticity and improving upper extremity function.

Surgical management to alleviate upper limb spasticity traditionally rely on lengthening the muscle-tendon units which often require a period of joint immobilization and extensive post-operative rehabilitation.  HSN is an innovative procedure with early clinical evidence that has been shown to disrupt the heightened neural reflex arc that causes upper limb spasticity without the need for any post-operative rehabilitation. 

The purpose of this study is to determine serum levels of baclofen in patients with spasticity managed with long-term intrathecal baclofen therapy. 

The purpose of this study is to demonstrate the non-inferiority of AbobotulinumtoxinA (aboBoNT-A) versus OnabotulinumtoxinA (onaBoNT-A) as the primary safety endpoint, and the superiority of aboBoNT-A over onaBoNT-A with respect to duration of response as the key secondary effectiveness endpoint when used at optimal doses according to approved prescribing information of each product.