Clinical Trials

The purpose of this research study is to evaluate imaging methods for detection and differentiation of thyroid nodules.

We want to determine the efficacy and safety, and the rate and type of side effects of this technique; as well as to delineate the clinical pathologic outcomes of the patients with thyroid cysts treated with Percutaneous ethanol injection (PEI) at Mayo Clinic, Rochester MN, since there is limited information of the use of this technique in the American literature.

The purpose of this study is to develop an ultrasound based detection and classification system that achieves high negative predictive value and specificity for malignancy, which could reduce unnecessary biopsies.

The purpose of this study is to explore how using different terms (with or without the word cancer) to identify papillary thyroid cancer might affect the decisions patients would make about treatment.

The purpose of this study is to measure the impact of thyroid ablation on patient’s thyroid-related symptoms using a pre-existing scoring system. 

The purpose of this study is to field test and update an existing conversation aid prototype designed to support shared decision making in the diagnosis and treatment of thyroid cancer, and to conduct a pilot randomized multi-center trial to test the refined conversation aid.

The purpose of this pilot study is to evaluate the effects of Radiofrequency Ablation (RFA) on thyroid hormones to treat thyroide nodules.

Radiofrequency ablation (RFA) of thyroid nodules would locally destroy follicular thyroid cells and could possibly impart conformational changes to the chemistry of thyroid hormones, thus altering their bioactive profiles. To evaluate this phenomenon, in vitro investigations to characterize qualitative and quantitve Mass Spectrometric chromatographic profile for thyroid hormones will be performed before and after RFA from patients undergoing ablation for thyroid nodules. {If there is a blood draw for clinical tests, we would request left over specimen from clinical ...

The objective of this project is to evaluate a treatment decision aid for patients with low risk thyroid cancer.

The purpose of this study is to evaluate microRNA biomarkers in the blood and fine-needle aspirate biopsies of thyroid nodules to determine their usefullness in pre-operative diagnosis, in particular to distinguish benign from cancerous thyroid nodules.

The objective of this study is to determine intensity of I-123 uptake in follicular thyroid lesions before surgery and correlate with final pathology findings.

The purpose of this study is to establish a human biobank of thyroid-derived tissues and blood samples from patients with thyroid disorders at Mayo Clinic in Rochester.

The purpose of this study is to perform a comprehensive immunophenotypic analysis of peripheral bloods samples from patients with benign and malignant thyroid disease. This data will be used to determine whether patients with advanced thyroid cancers have significantly altered numbers and/or subtypes of circulating immune cells, in particular immunosuppressive monocytes.