Clinical Trials

The purpose of this study is to examine characteristic (electrophysiological) of ventricular arrhythmias, ablation technique and outcomes in patients with prosthetic valve.

This study is being done to determine whether there is an increase in sympathetic nerve activity before the onset of ventricular arrhythmias.

The purpose of this study is to utilize neuECG, a new method to directly and non-invasively record skin sympathetic nerve activity (SKNA) and electrocardiogram (ECG), to non-invasively assess the effects radiofrequency catheter ablation (RFCA) on SKNA in patients at high risk for life-threatening ventricular arrhythmias (VA).

The aim of the present study is to assess the use of high-resolution imaging data from CT and or MRI processed in 3D meshes with the use of the MUSIC software (inHEART, Bordeuax, France) and integrated within the EP lab environment to assist catheter ablation procedures. The MUSIC software is a proprietary software developed by cardiac electrophysiology and radiology researchers at the University of Bordeuax, France, that allows high-resolution recostruction of CT and MRI cardiac imaging for integration into electroanatomic maps in ablation procedures2,3.

The purpose of this study is to obtain electro-anatomic maps of human myocardium in sinus rhythm and ventricular arrhythmias to identify activation patterns, identify and perform tissue ablation at targeted sites of interest that could play an important trigger for development of arrhythmias, and to perform histologic analysis of the myocardial tissue to identify triggers and/or targets for therapies to terminate ventricular arrhythmias.

The purpose of this study is to compare the rate of arrhythmia-induced events between paediatric Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) patients with and without implantable cardioverter defibrillator (ICDs), and to determine the quality of life and psychosocial functioning of paediatric CPVT patients with and without ICDs.

The purpose of this study is to measure the effect on ventricular ectopy, safety, tolerability and pharmacokinetics of S48168 (ARM210) compared with placebo in participants with Type 1 Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT1).

The purpose of the MODULAR ATP Clinical Study is to demonstrate safety, performance, and effectiveness of the Modular Cardiac Rhythm Management (mCRM) Therapy System.

The purpose of this study is to determine prevalence of sleep apnea in patients with hypertrophic cardiomyopathy and the risk of atrial and ventricular arrhythmias.

The purpose of this study is to collect and review the Mayo Clinic experience with left cardiac sympathetic denervation (LCSD) in patients with heritable arrhythmias syndromes or refractory ventricular arrhythmias beginning in 2000.

The purpose of this study is to evaluate the feasibility and safety of a management approach that incorporates VT-ablation and S-ICD implantation in secondary prevention patients. This is a single arm prospective study with 30 patients eligible for implantation of an ICD for the secondary prevention of sudden cardiac death.

The purpose of this study is to learn about the effect of atrial fibrillation on memory and thinking. This study helps us to determine how often memory problems occur in patients with atrial fibrillation and identify factors that influence changes in memory and thinking.

The purpose of this study is to identify and characterize heart rhythm disorders including atrial arrhythmias such as atrial fibrillation, ventricular arrhythmias such as ventricular tachycardia, conduction abnormalities, etc. among patients with spontaneous coronary artery dissection (SCAD).

The purpose of this study is to determine the incidence of atrial and ventricular arrhythmias in patients with hypertrophic cardiomyopathy, with and without sleep apnea.